Table 2 Baseline characteristics of the ILD patients
Variables | Overall (n = 67) | IPF (n = 35) | CTD-ILD (n = 32) | P (IPF versus CTD-ILD) |
|---|---|---|---|---|
Male, n (%) | 36 (56.3) | 24 (68.6) | 12 (37.5) | 0.029 |
Age (years) | 64 ± 10 | 66 ± 8 | 62 ± 11 | 0.418 |
Current smoker, n (%) | 12 (18.8) | 7 (20.0) | 5 (17.2) | 0.78 |
Smoking index | 30 (0 ~ 487) | 100 (0 ~ 500) | 0 (0 ~ 475) | 0.465 |
Underlying diseases, n (%) | ||||
Hypertension | 22 (34.4) | 16 (45.7) | 6 (20.7) | 0.053 |
Diabetes | 19 (29.7) | 12 (34.3) | 7 (24.1) | 0.376 |
Cardiovascular disease | 18 (28.1) | 11 (31.4) | 7 (24.1) | 0.518 |
Cerebrovascular disease | 6 (9.4) | 4 (11.4) | 2 (6.9) | 0.536 |
Subtypes of CTD, n (%) | ||||
Rheumatoid arthritis | N/A | 10 (31.3) | ||
Sjogren’s syndrome | N/A | 9 (28.1) | ||
Systemic lupus erythematosus | N/A | 5 (15.6) | ||
Dermatomyositis | N/A | 2 (6.3) | ||
Systemic Sclerosis | N/A | 2 (6.3) | ||
Mixed connective tissue disease | N/A | 4 (12.5) | ||
Radiologic patterns of ILD, n(%) | 0.08 | |||
UIP | 33 (94.3) | 23 (79.3) | ||
Probable UIP | 2 (5.7) | 6 (20.7) | ||
The onset of symptoms to hospital admission (days) | 60 (20 ~ 173) | 60 (30 ~ 123) | 65 (19 ~ 372) | 0.632 |
Length of hospital stay | 13 (8 ~ 10) | 9 (7 ~ 14) | 13 (9 ~ 11) | 0.524 |
Laboratory data at admission | ||||
Lactate (mmol/L) | 1.00 (0.80 ~ 1.40) | 1.20 (0.90 ~ 1.50) | 0.90 (0.75 ~ 1.20) | 0.107 |
White blood cell(×109/L) | 6.97 ± 2.10 | 6.89 ± 1.82 | 7.0 ± 2.42 | 0.080 |
Neutrophil granulocyte (×109/L) | 3.84 (2.99 ~ 4.79) | 3.87 (3.23 ~ 4.76) | 3.79 (2.97 ~ 5.18) | 0.599 |
Lymphocyte (×109/L) | 1.88 ± 0.67 | 1.92 ± 0.67 | 1.82 ± 0.68 | 0.951 |
Haemoglobin (g/L) | 133.18 ± 17.02 | 136.02 ± 15.41 | 130.5 ± 18.6 | 0.184 |
Platelet (×109/L) | 217.92 ± 53.38 | 208.82 ± 43.70 | 228.90 ± 62.17 | 0.144 |
C-reactive protein (mg/L) | 5.0 (5.0 ~ 10.8) | 5.0 (1.0 ~ 9.0) | 6.0 (5.0 ~ 13.8) | 0.071 |
Procalcitonin (ng/ml) | 0.05 (0.05 ~ 0.05) | 0.05 (0.05 ~ 0.05) | 0.05 (0.05 ~ 0.05) | 0.876 |
ESR (mm/h) | 20.0 (9.3 ~ 40.0) | 15.0 (5.0 ~ 35.0) | 30.0 (10.0 ~ 47.5) | 0.036 |
ALT (U/L) | 16.5 (11.7 ~ 21.0) | 17.6 (12.0 ~ 23.6) | 16.0 (10.8 ~ 20.0) | 0.128 |
AST (U/L) | 20.1 (17.1 ~ 24.4) | 20.1 (17.0 ~ 25.5) | 20.0 (17.7 ~ 24.3) | 0.898 |
Creatinine (umol/L) | 69.8 ± 13.7 | 72.3 ± 14.2 | 66.7 ± 12.6 | 0.529 |
D-Dimer (mg/L) | 0.15 (0.08 ~ 0.26) | 0.13 (0.07 ~ 0.25) | 0.16 (0.095 ~ 0.40) | 0.292 |
Pulmonary function test | ||||
TLC% pred | 73.8 ± 12.4 | 73.7 ± 11.4 | 73.8 ± 13.8 | 0.282 |
FVC% pred | 82.9 ± 17.9 | 85.6 ± 16.2 | 79.6 ± 19.53 | 0.590 |
FEV1% pred | 85.4 ± 16.1 | 88.4 ± 15.3 | 81.8 ± 16.5 | 0.793 |
DLCO% pred | 66.1 ± 11.6 | 68.5 ± 11.6 | 63.1 ± 11.1 | 0.874 |
S1P level in serum (ng/ml) | 252.7 (162.3 ~ 697.3) | 244.49 (142.8 ~ 793.2) | 264.0 (175.6 ~ 587.0) | 0.931 |