Table 1 Data source of genetic variables used for MR analysis
Phenotype | Type of trait | Consortium | Sample size | No. case | PMID |
|---|---|---|---|---|---|
COPD | Binary | FinnGen | 358,369 | 20,066 | NA |
FEV1 | Continuous | UK Biobank; SpiroMeta | 400,102 | NA | 30,804,560 |
FVC | Continuous | UK Biobank; SpiroMeta | 400,102 | NA | 30,804,560 |
FEV1/FVC | Continuous | UK Biobank; SpiroMeta | 400,102 | NA | 30,804,560 |
Preserved ratio impaired spirometry (PRISm) | Binary | UK Biobank; | 296,282 | 38,639 | 38,097,206 |
Brian cortex surface area | Continuous | ENIGMA | 51,665 | NA | 32,193,296 |
Brian cortex thickness | Continuous | ENIGMA | 51,665 | NA | 32,193,296 |