Table 1 Predictors of SAP: univariable analysis
Variables | SAP(n = 281) | Non-SAP(n = 997) | P-value |
|---|---|---|---|
Demographics | |||
 Age ≥ 67 | 45.9% (n = 129/281) | 27.7% (276/997) | 0.000 |
 Gender (male/total) | 74.4% (n = 209/281) | 68.7% (n = 685/997) | 0.067 |
Lifestyle-related variables | |||
 Current drinking | 35.9% (n = 101/281) | 34.9% (n = 348/997) | 0.747 |
 Current smoking | 33.8% (n = 95/281) | 28.1% (n = 280/997) | 0.063 |
Clinical variables | |||
 post-stroke vomiting | 27.9% (n = 78/280) | 24.6% (n = 245/996) | 0.268 |
 Dysphagia | 17.5% (n = 48/275) | 7.4% (n = 73/980) | 0.000 |
 Transpharyngeal intubation | 59% (n = 164/278) | 19.7% (n = 194/984) | 0.000 |
 Post-stroke PPI usage | 46.7% (n = 128/281) | 37.1% (n = 364/997) | 0.004 |
Coexisting disease | |||
 Hypertension | 90.7% (n = 255/281) | 90.3% (n = 900/997) | 0.811 |
 Diabetes mellitus | 18.9% (n = 53/281) | 19.8% (n = 197/997) | 0.737 |
 Ischemic heart disease | 5.3% (n = 15/281) | 5.6% (n = 56/997) | 0.857 |
 Atrial fibrillation | 3.2% (n = 9/281) | 1.8% (n = 18/997) | 0.150 |
 Hyperlipidemia | 22.8% (n = 64/281) | 26.7% (n = 266/997) | 0.187 |
 Hyperuricemia | 5.0% (n = 14/281) | 4.5% (n = 45/997) | 0.741 |
Laboratory index | |||
 BMI index, n (%) |  |  | 0.297 |
 < 18.5 | 9.9% (n = 8/81) | 5.5% (n = 23/416) |  |
 18.5–24 | 40.7% (n = 33/81) | 45.7% (n = 190/416) |  |
 ≥ 24 | 49.4% (n = 40/81) | 48.8% (n = 203/416) |  |
 Neutrophils/lymphocyte, median (IQR) | 6.09 (10.14, 3.9) | 4.25 (2.67, 7.57) | 0.000 |
Admission systolic blood pressure, mean ± SD | 164.83 ± 25.85 | 160.15 ± 24.12 | 0.044 |
Admission diastolic blood pressure, median (IQR) | 91 (80, 100) | 90 (80, 100) | 0.812 |
Discharge mRS ≥ 3 | 81.5% (n = 229/281) | 51.2% (n = 510/997) | 0.000 |
Hospitalization duration (day), median (IQR) | 17 (13, 22) | 14 (11, 18) | 0.000 |
Death within 30-day discharge | 0.7%(n = 2/281) | 0.3%(n = 3/997) | 0.665 |
Death within 90-day discharge | 2.1% (n = 6/281) | 0.8% (n = 8/997) | 0.116 |
NIHSS score ≥ 10 | 59.1% (n = 166/281) | 29.4% (n = 293/997) | 0.000 |
Radiological variables | |||
 Haematoma volume (ml), median (IQR) | 7.83(2.94,15.27) | 7.62(3.22,14.22) | 0.789 |
 Cortical involvement | 35.2% (n = 99/281) | 32.8% (n = 327/997) | 0.445 |
 Deep involvement | 78.3% (n = 220/281) | 75.4% (n = 752/997) | 0.320 |
 Infratentorial involvement | 8.9% (n = 25/281) | 12.0% (n = 120/997) | 0.166 |
 Multilobar involvement | 34.2% (n = 96/281) | 15.5% (n = 155/997) | 0.000 |
 Extension into ventricle | 35.6% (n = 100/281) | 19.4% (n = 193/997) | 0.000 |
 Total CSVD burden score | 1 (1, 2) | 1 (1, 2) | 0.000 |
Follow-up duration (day), median (IQR) | 1624 (1065, 2544) | 1945 (1274, 2715) | 0.000 |