Fig. 5
From: Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice
Zafirlukast effectively mitigates lung inflammation induced by LPS by the regulation of the TLR4/NF-KB/NLRP3 pathway in vivo. A-B MYD88, TLR4, P65, P-P65, NLRP3, caspase1, Cleaved-caspase1, IL-1β and Cleaved-IL-1β protein levels in lung homogenate were assessed using Western blot (A), Below is the analysis of the corresponding optical density. B. C Immunohistochemical analysis was performed to assess the expression levels of MYD88 and P-P65 in lung tissue sections, and quantitative results were obtained. Data are expressed as mean ± SD (n = 3). Statistical significance was denoted as #P < 0.05, ##P < 0.01 compared with control group, *P < 0.05, **P < 0.01 compared with model group