Fig. 6
From: Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice
Zafirlukast effectively reduces lung inflammation induced by BLM by regulating the TLR4/NF-KB/NLRP3 pathway in vivo. A-B The Western blot method was used to assess the protein levels of MYD88, TLR4, P65, P-P65, NLRP3, caspase1, Cleaved-caspase1, IL-1β, and Cleaved-IL-1β in lung homogenate. A The following analysis of optical density is presented below. B. C Identification via immunohistochemistry and quantification of MYD88 and P-P65 expression levels in sections of lung tissue. Data are expressed as mean ± SD (n = 3). #P < 0.05, ##P < 0.01, ###P < 0.001 compared with control group, *P < 0.05, **P < 0.01, ***P < 0.001 compared with model group