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Table 3 Baseline CT and pulmonary function test of participants, according to pulmonary function categories at registration

From: Update of prognosis and characteristics of chronic obstructive pulmonary disease in a real-world setting: a 5-year follow-up analysis of a multi-institutional registry

 

FEV1/FVC < 70%

 

FEV1/FVC

≥ 70%

 

mild and moderate

(n = 197)

severe

(n = 112)

very severe

(n = 65)

Dunnett test*

(n = 53)

P-value†

LAA (%), median (IQR)

43.5

(33.7–53.1)

49.2

(40.5–57.7) §

62.8

(55.6–69.0) §

0.004/<0.001

34.9

(27.8–51.0)

0.014

TLC (L), median (IQR)

5.21 (4.43–5.89)

5.13 (4.30–5.98)

5.66 (5.24–6.56) §

0.751/<0.001

4.68

(3.86–5.38)

0.006

%TLC (%), median (IQR)

97.4

(85.5-108.5)

98.9

(88.3-109.9)

109

(99.2-120.3) §

0.951/<0.001

87.5

(77.6-102.2)

0.001

VC (L), median (IQR) ‡

3.40

(2.85–3.88)

2.64

(2.10–3.07) §

2.13

(1.88–2.60) §

< 0.001/<0.001

3.02

(2.35–3.40)

< 0.001

%VC (%), median (IQR)‡

100.6

(89.0-111.1)

80.5

(70.7–89.5) §

65.8

(55.9–75.4) §

< 0.001/<0.001

86.8

(72.2–95.0)

< 0.001

FVC (L), median (IQR)

3.25

(2.75–3.81)

2.39

(1.98–2.95) §

1.80

(1.43–2.22) §

< 0.001/<0.001

2.82

(2.12–3.19)

< 0.001

FEV1 (L), median (IQR)

1.79

(1.51–2.16)

1.00

(0.85–1.17) §

0.61

(0.51–0.69) §

< 0.001/<0.001

2.10 (1.81–2.45)

< 0.001

%FEV1 (%),

median (IQR)

68.3

(58.6–81.1)

40.5

(35.3–45.0) §

23.0

(19.9–25.5) §

< 0.001/<0.001

82.8 (71.3–92.7)

< 0.001

RV/TLC (%),

median (IQR) ‡

35.9

(27.3–42.3)

46.6

(41.7–55.1) §

61.8

(56.9–67.8) §

< 0.001/<0.001

36.9 (27.0–48.0)

0.182

%RV (%),

median (IQR) ‡

100.2

(76.8-119.7)

132.7

(116.5-151.5) §

177.9

(163.3-191.6) §

< 0.001/<0.001

108.2

(77.5-128.9)

0.132

  1. FVC, Forced vital capacity; FEV1, Forced expiratory volume in one second; IQR, Interquartile range; VC, Vital capacity; TLC, Total lung capacity; RV, Residual volume; LAA, Low attenuation area
  2. *: Reference: mild and moderate AFL group
  3. †: Wilcoxon rank sum test
  4. ‡: Numbers of patients (mild and moderate AFL, severe AFL, very severe AFL, and FEV1/FVC ≥ 70%, respectively) were as follows: VC, %VC, RV/TLC and %RV/TLC (N = 197, 111, 64, 53)
  5. §: P < 0.05 with Dunnett’s test or Wilcoxon rank sum test
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BMC Pulmonary Medicine

ISSN: 1471-2466

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