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Table 1 The expression profiles of selected genes in ABCD group

From: Increased Lipocalin 2 detected by RNA sequencing regulates apoptosis and ferroptosis in COPD

Gene-id

Log2 ratio (cases/controls)

A

B

C

D

CAMP

2.74

0.73

2.58

2.61

DEFA4

3.18

0.45

2.55

2.03

ELANE

2.59

0.85

2.35

2.04

LCN2

1.95

0.78

2.26

2.29

LTF

2.82

0.67

2.76

2.82

DEFA1

2.97

1.49

3.14

2.89

DEFA1B

2.18

0.53

2.60

2.22

RNASEK-C17orf49

0.93

0.55

0.52

0.42

RNA45S5

3.02

2.10

2.51

0.84

RPSAP58

1.91

4.09

4.27

2.44

HP

3.24

2.52

2.69

0.79

LGALS9B

-1.12

-1.03

-0.92

-0.79

LGALS9C

-0.91

-0.64

-0.58

-0.44

HSPA1B

-0.71

-0.60

-0.62

-1.25

MAP3K7CL

-1.61

-0.44

-1.08

-0.98

DCAF4

-0.79

-0.79

-1.15

-0.62

SIGLEC14

-2.03

-0.93

-0.61

-0.81

RNA5-8S5

-2.49

-1.74

-1.28

-1.34

ZNF683

-0.47

-1.72

-0.51

-0.76

  1. A-group (low risk, less symptoms GOLD 1–2 mild or moderate airflow limitation, 0–1 exacerbations per year, and mMRC grade 0–1 or CAT score < 10), B-group (low risk, more symptoms GOLD 1–2 mild or moderate airflow limitation, 0–1 exacerbations per year, and mMRC grade ≥ 2 or CAT score ≥ 10), C-group (high risk, less symptoms GOLD 3–4 severe or very severe airflow limitation, and/or ≥ 2 exacerbations per year, and/or ≥ 1 hospitalized exacerbation per year, and mMRC grade 0–1 or CAT score < 10), D-group (high risk, more symptoms GOLD 3–4 severe or very severe airflow limitation, and/or ≥ 2 exacerbations per year, and/or ≥ 1 hospitalized exacerbation per year, and mMRC grade ≥ 2 or CAT score ≥ 10)
  2. Abbreviations: CAMP cathelicidin antimicrobial peptide, DEFA4 defensin alpha 4, ELANE elastase, neutrophil expressed, LCN2 lipocalin 2, LTF lactotransferrin, RNA45S5 RNA, 45S pre-ribosomal 5, RPSAP58 ribosomal protein SA pseudogene 58, HP haptoglobin, LGALS9B galectin 9B, LGALS9C galectin 9C, HSPA1B heat shock protein family A (Hsp70) member 1B, MAP3K7CL MAP3K7 C-terminal like, DCAF4 DDB1 and CUL4 associated factor 4, SIGLEC14 sialic acid binding Ig like lectin 14, RNA5-8S5 RNA, 5.8S ribosomal 5, ZNF683 zinc finger protein 683
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BMC Pulmonary Medicine

ISSN: 1471-2466

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