Table 3 Significant up and downregulated miRNAs between high and low BDR group in the GACRS. Base Mean: normalized mean counts in reference group. Log2FC: base-2-fold change from high to Low BDR. p-value: computed with DESeq2. Beta and odds ratio from negative binomial regression are for a doubling of miR counts
From: Circulating microRNAs associated with bronchodilator response in childhood asthma
| Â | DeSeq2 | Negative Binomial Regression | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
miRNA | baseMean | log2FoldChange | Pvalue | FDR q value | Beta | CI (Upper) | CI (Lower) | OR | pvalue | FDR q value |
miR-1246 | 212.193 | -0.623 | 0.00056 | 0.0221 | -0.4343 | -0.1839 | -0.6853 | 0.6477 | 5.15E-04 | 6.29E-04 |
miR-1290 | 20.946 | -0.749 | 0.00003 | 0.00637 | -0.5424 | -0.3119 | -0.7735 | 0.5814 | 8.97E-06 | 9.87E-05 |
miR-143-3p | 37205.6 | -0.392 | 0.00007 | 0.0073 | -0.2719 | -0.1347 | -0.4091 | 0.7619 | 6.66E-05 | 2.44E-04 |
miR-200b-3p | 88.291 | 1.171 | 0.0001 | 0.0073 | 0.8175 | 1.2154 | 0.4211 | 2.2648 | 1.44E-04 | 3.18E-04 |
miR-223-3p | 2825.22 | -0.482 | 0.00226 | 0.0716 | -0.3336 | -0.1105 | -0.5567 | 0.7163 | 2.93E-03 | 3.22E-03 |
miR-26b-5p | 3143.41 | -0.525 | 0.00004 | 0.00637 | -0.3648 | -0.1863 | -0.5431 | 0.6943 | 4.48E-05 | 2.44E-04 |
miR-378a-3p | 2849.76 | -0.438 | 0.00024 | 0.0126 | -0.3065 | -0.1396 | -0.4732 | 0.736 | 3.33E-04 | 5.23E-04 |
miR-378i | 26.698 | -0.421 | 0.00212 | 0.0716 | -0.3703 | -0.1697 | -0.5707 | 0.6906 | 1.92E-04 | 3.52E-04 |
miR-500b-3p | 145.668 | -0.753 | 0.00033 | 0.015 | -0.5193 | -0.2 | -0.8373 | 0.5949 | 4.28E-04 | 5.88E-04 |
miR-877-5p | 976.479 | -0.646 | 0.00326 | 0.094 | -0.4519 | -0.1466 | -0.7573 | 0.6364 | 3.42E-03 | 3.42E-03 |
miR-885-5p | 50.444 | -1.419 | 0.00012 | 0.0073 | -0.9849 | -0.5166 | -1.4523 | 0.3735 | 1.38E-04 | 3.18E-04 |