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Table 5 Association between log hs-TnT levels and study parameters in all subjects

From: Assessment of novel cardiovascular biomarkers in chronic obstructive pulmonary disease

 

Subjects (n = 120)

Pre-COPD (n = 23)

COPD (n = 97)

ρ

p-value

ρ

p-value

ρ

p-value

Age

0.526

< 0.001

0.672

< 0.001

0.445

< 0.001

Pulmonary function test

      

 FVC

-0.223

0.015

-0.318

0.140

-0.199

0.051

 FEV1

-0.388

< 0.001

-0.309

0.152

-0.326

0.001

 FEV1%predicted

-0.353

< 0.001

-0.136

0.536

-0.263

0.009

 IC

-0.174

0.057

0.089

0.688

-0.267

0.008

 %Dlco/VA

-0.165

0.071

0.202

0.356

-0.154

0.133

Chest HRCT

      

 LAA% for the upper lung field

0.046

0.617

-0.085

0.700

-0.075

0.465

Echocardiography

      

 LVDd

0.066

0.48

0.431

0.040

0.041

0.697

 EF

0.194

0.036

0.593

0.003

0.145

0.164

 E/A

-0.390

< 0.001

-0.657

< 0.001

-0.240

0.021

 DT

0.299

0.001

0.488

0.018

0.246

0.018

 E/E'

0.146

0.12

0.396

0.061

0.145

0.168

 RVSP

0.202

0.032

0.274

0.229

0.169

0.108

 CO

0.217

0.019

0.303

0.160

0.193

0.064

Six-minute walking test

      

 Walking distance

-0.444

< 0.001

-0.693

< 0.001

-0.393

< 0.001

 Borg scale

0.348

< 0.001

0.231

0.289

0.324

0.001

 Initiate SpO2

-0.054

0.56

0.006

0.979

0.014

0.894

 Minimal SpO2

-0.168

0.067

-0.087

0.695

-0.104

0.312

 Initiate PR

0.046

0.616

0.402

0.057

-0.059

0.566

 Maximal PR

-0.157

0.086

-0.329

0.125

-0.103

0.314

Blood test

      

 hs-CRP

0.212

0.002

0.176

0.423

0.233

0.021

 Gal-3

0.177

0.053

-0.032

0.887

0.163

0.111

 NT-proBNP

0.437

< 0.001

0.206

0.346

0.454

< 0.001

 SP-D

-0.011

0.908

-0.121

0.583

0.005

0.959

 IL-6

0.490

< 0.001

0.594

0.003

0.453

< 0.001

 CC16

0.120

0.190

0.051

0.819

0.182

0.074

 sRAGE

-0.064

0.485

-0.332

0.122

0.047

0.650

  1. Boldface indicates a P value with statistical significance. FVC; forced vital capacity, FEV1%; forced expiratory volume in 1 second, IC; inspiratory capacity, %DLco/VA; percent diffusing capacity of the lung for carbon monoxide/alveolar volume, HRCT; high-resolution computer tomography, LAA; percentage of low attenuation area, LVDd; left ventricular end-diastolic dimension, EF; ejection fraction, E/A; early diastolic filling velocity/atrial filling velocity ratio, DT; deceleration time, E/E’; early diastolic filling velocity/early diastolic mitral annular velocity, RVSP; right ventricular systolic pressure, CO; cardiac output, SpO2; oxygen saturation, PR; pulse rate, hs-CRP; high-sensitivity C-reactive protein, hs-TnT; high-sensitivity cardiac troponin T, NT-proBNP; N-terminal pro-brain natriuretic peptide, SP-D; surfactant protein D, IL-6; interleukin 6, CC16; club cell protein 16, sRAGE; soluble receptor for advanced glycation end products
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BMC Pulmonary Medicine

ISSN: 1471-2466

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