Table 2 Grade 3–4 AEs of neoadjuvant therapy
Variables | Unmatched cases | Matched cases | ||||
|---|---|---|---|---|---|---|
< 65Y, n = 71 | ≥ 65Y, n = 108 | P-value | < 65Y, n = 66 | ≥ 65Y, n = 66 | P-value | |
Any AEs, n (%) | 11 (15.5) | 23 (21.3) | 0.333 | 11 (16.7) | 9 (13.6) | 0.627 |
Hematologic | ||||||
Leukopenia | 1 (1.4) | 5 (4.6) | 0.455 | 1 (1.5) | 2 (3.0) | 1.000 |
Agranulocytosis | 0 (0.0) | 4 (3.7) | 0.261 | 0 (0.0) | 1 (1.5) | 1.000 |
Anemia | 6 (8.5) | 10 (9.3) | 0.853 | 6 (9.1) | 4 (6.1) | 0.742 |
Thrombocytopenia | 1 (1.4) | 5 (4.6) | 0.455 | 1 (1.5) | 1 (1.5) | 1.000 |
Gastrointestinal | ||||||
Nausea | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Emesis | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Diarrhea | 0 (9.9) | 1 (0.9) | 1.000 | 0 (9.9) | 0 (0.0) | NA |
Constipation | 0 (0.0) | 3 (2.8) | 0.412 | 0 (0.0) | 1 (1.5) | 1.000 |
Hepatic injury | 1 (1.4) | 3 (2.8) | 0.929 | 1 (1.5) | 1 (1.5) | 1.000 |
Renal injury | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Immune myocarditis | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Immune pneumonia | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Skin reaction | 2 (2.8) | 5 (4.6) | 0.827 | 2 (3.0) | 1 (1.5) | 1.000 |
Hypothyroidism | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Coagulation disorders | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |
Sensory neurotoxicity | 0 (0.0) | 0 (0.0) | NA | 0 (0.0) | 0 (0.0) | NA |