CD4/CD8 T-cell ratio in bronchoalveolar lavage fluid as a marker of sarcoidosis severity: a retrospective study

BMC Pulmonary Medicine

Table 1 Clinical characteristics of patients with R values ≥ 3.5 and < 3.5

Characteristic n (%)	Total n = 62	R ≥ 3.5 n = 31	R < 3.5 n = 31	*p-Value*
Median age at BAL (range)	43.5 (19–72)	43 (19–72)	44 (23–68)	0.921
Sex [n (%)]
Male	35 (56.5)	17 (54.8)	18 (58.1)	0.798
Female	27 (43.5)	14 (45.2)	13 (42)	0.798
Intrathoracic lymph node [n (%)]	61 (98.4)	31 (100)	30 (96.8)	1.000^§
Parenchymal involvement [n (%)]	46 (74.2)	21 (67.7)	25 (80.6)	0.246
Phenotypes [n (%)]
Isolated lung involvement	13 (20.9)	7 (22.6)	6 (19.4)	0.755
Musculoskeletal-cutaneous	25 (40.3)	15 (48.4)	10 (32.3)	0.196
Abdominal involvement	12 (19.4)	2 (6.5)	10 (32.3)	0.02^§
“OCCC”	12 (19.4)	6 (19.4)	6 (19.4)	1.000^§
Ocular	4 (6.5)	4 (12.9)	0 (0)	0.113^§
CCC	8 (12.9)	2 (6.5)	6 (19.4)	0.255^§
Extrapulmonary involvement*	4 (6.5)	2 (6.5)	2 (6.5)	0.255^§

Abbreviations: R CD4/CD8 ratio, BAL bronchoalveolar lavage, OCCC ocular–cardiac–cutaneous–central nervous system, CCC cardiac–cutaneous–central nervous system
^*All had intra- and extra-pulmonary node involvement without other extrapulmonary manifestations, except for one with otorhinolaryngologic involvement (in the R ≥ 3.5 group)
^§Fishers’ test with exact p-value

ISSN: 1471-2466