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Table 2 Respiratory findings according to R value

From: CD4/CD8 T-cell ratio in bronchoalveolar lavage fluid as a marker of sarcoidosis severity: a retrospective study

Characteristics n (%)

Total

n = 62

R ≥ 3.5

n = 31

R < 3.5

n = 31

p-value

BAL’s data

 Total cell count (× 103/ml) [median (IQR)]

160 (100–250)

145 (97–235)

160 (100–275)

0.471

 Cell population % mean (SD)

  Lymphocytes

24.5 (15.9)

28.4 (15.7)

20.8 (15.5)

0.071

  Macrophages

69 (5.2)

66.3 (14.8)

71.7 (15.3)

0.184

  Eosinophils

0.6 (1.8)

0.7 (1.8)

0.6 (1.7)

0.732

  Neutrophils

5.2 (7.1)

4.7 (8.1)

5.7 (6.0)

0.599

 CD4/CD8 ratio [median (IQR)]

3.45 (1.88–7.26)

6.84 (4.78–11.32)

1.91 (1.28–2.81)

 < 0.001

PFTs data

n = 59

n= 31

n= 28

 

 FEV-1 (L) [median (IQR)]

2.94 (2.34–3.56)

3.07 (2.57–3.74)

2.75 (1.84–3.42)

0.069

 FVC (L) [median (IQR)]

3.8 (2.92–4.48)

3.89 (3.24–5.01)

3.53 (2.47–4.15)

0.092

 DLCO (%) [median (IQR)]

76 (66–87)

81 (70–86)

68 (60–88)

0.057

CT-scan review [median (IQR)]**

n= 29

n= 13

n= 16

 

 Micronodular involvement [n (%)]

  Sparce

13 (44.8)

5 (38.5)

8 (50.0)

0.534

  Profuse

7 (24.1)

3 (23.1)

4 (25.0)

1.000§

  Consolidation/conglomeration

9 (31.0)

5 (38.5)

4 (25.0)

0.688§

 Traction bronchiectasis [n (%)]

1 (3.4)

0 (0)

1 (6.3)

1.000§

  1. Consolidation: Homogeneous increase in pulmonary parenchymal attenuation which obscures vessels and airway walls; Conglomeration: a large opacity > 3 cm surrounding and encompassing hilar bronchi and vessels; Traction bronchiectasis: irregular bronchial dilatation due to surrounding fibrosis. Definition of terms for abnormalities on HRCT from Fleischner Glossary [26]
  2. Abbreviations: BAL Bronchoalveolar lavage, PFTs Pulmonary function tests, FEV-1 Forced expiratory volume, FVC Forced vital capacity, DLCO Diffusing capacity of the lung for carbon monoxide, IQR interquartile range, SD standard deviation
  3. *Restrictive pulmonary disease and/or obstructive pulmonary disease
  4. **CT-scans review for sarcoidosis patients with parenchymal involvement was available for 29 patients (13 with R ≥ 3.5 and 16 with R < 3.5)
  5. §Fisher Test with exact p-value