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Table 4 Therapeutic management of patients with sarcoidosis according to R value

From: CD4/CD8 T-cell ratio in bronchoalveolar lavage fluid as a marker of sarcoidosis severity: a retrospective study

Treatment received

Total

n = 62

R ≥ 3.5

n = 31

R < 3.5

n = 31

p-value

Treatment required

33 (53.2)

11 (35.5)

22 (71)

0.01

Steroids

32 (96.9)

11 (100)

21 (95.5)

1.000

Immunosuppressor agent

16 (48.5)

4 (36.4)

12 (54.5)

0.040§

 Methotrexate

7 (43.8)

2 (50)

5 (41.7)

0.425§

 TNF inhibitor

8 (50)

1 (25)

7 (58.3)

0.053§

 Mycophenolate mofetil

6 (37.5)

2 (50)

4 (33.3)

0.671§

 Cyclophosphamide

3 (18.8)

0 (0)

3 (25)

0.238§

Lines of immunosuppressive therapy [n (%)]

 —1

9 (56.3)

3 (75)

6 (50)

0.703§

 —2

6 (37.5)

1 (25)

5 (41.7)

 

 —≥ 3

1 (6.3)

0 (0)

1 (8.3)

 
  1. Abbreviation: TNF tumour necrosis factor
  2. § Fisher’s test with exact p-value