NLRP3 is a BMI-independent mediator of stable COPD

BMC Pulmonary Medicine

Table 1 Baseline characteristics of the COPD and control groups

	COPD	n	Controls	n	p-value
Background features
Sex (F, n (%))	9 (31)	29	16 (50)	32	0.193
Age (years)	66 ± 12	29	54 ± 9	31	< 0.001
Active smoking (n, %)	7 (24.1)	29	10 (34.5)	29	0.565
Smoking pack-years	45 (45)	29	1 (20.5)	31	< 0.001
Body measures and composition analysis
Weight (kg) Height (cm) BMI (kg/m²) Total fat mass Fat percentage (%) Fat-free mass Total body water	73.6 ± 20.8 164.4 ± 9.4 26.8 (7.7) 19.8 ± 14.4 27.2 ± 11.4 51.6 (17.9) 37.8 (13.1)	29 29 29 26 28 26 26	83.4 ± 15.6 166 ± 10.1 30.2 (6.8) 26.5 ± 9.7 31.3 ± 11 55.4 (13.8) 40.5 (10.1)	28 28 28 28 28 28 28	0.049 0.533 0.048 0.054 0.180 0.354 0.354
Comorbidities
Coronary artery disease (n, %) Hyperlipidemia (n, %) Hypertension (n, %) Diabetes mellitus (n, %) Obesity (n, %)	6 (20.7) 4 (13.8) 15 (51.7) 9 (31) 8 (27.6)	29 29 29 29 29	4 (13.3) 2 (6.7) 9 (30) 6 (20) 15 (53.6)	30 30 30 30 28	0.506 0.424 0.115 0.381 0.061

Fisher’s exact test was performed to determine the associations between COPD status and the variables of sex, active smoking, and comorbidity. Continuous variables with a nonnormal distribution, such as smoking pack-years, BMI, fat-free mass and total body water, were analyzed with the Mann‒Whitney U test, and the data are presented as median(IQR). Continuous variables with normal distributions, such as age, weight, height, total fat mass and fat percentage, were analyzed with t-test and the data are presented as mean ± SD. *BMI: body mass index, F: female

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