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Table 5 COPD and control subjects are grouped according to their BMI

From: NLRP3 is a BMI-independent mediator of stable COPD

 

COPD

Control

 

Obese

Nonobese

Obese

Nonobese

NLRP3

7.66 (11.33)

1.82 (1.76)

0.25 (1.63)

0.30 (0.82)

Caspase-1

1.18 (2.72)

1.10 (3.20)

0.81 (1.14)

1.06 (1.49)

IL-1β

1.59 (1.93)

1.76 (1.22)

0.52 (0.58)

1.10 (0.97)

IL-17 A

1.50 (4.88)

1.60 (3.48)

0.28 (1.23)

0.62 (0.82)

Comparison

p-values

 

NLRP3

Caspase-1

IL-1β

IL-17A

Obese COPD vs. Nonobese COPD

0.263

0.341

0.639

0.652

Obese COPD vs. Obese control

0.076

0.624

0.591

0.104

Nonobese COPD vs. Nonobese control

0.039*

0.267

0.193

0.375

Nonobese COPD vs. Obese control

0.320

0.103

0.072

0.067

Nonobese control vs. Obese control

0.817

0.406

0.282

0.277

Obese COPD vs. Nonobese control

0.091

0.901

0.562

0.364

  1. The Mann‒Whitney U test was used to analyze the data. * indicates statistical significance (p < 0.050). Sample sizes: obese COPD patients, n = 8; nonobese COPD patients, n = 21; obese controls, n = 19; nonobese controls, n = 17. COPD: chronic obstructive pulmonary disease, IL: Interleukin, NLRP3: NLR family pyrin domain-containing 3