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Table 1 Association between clinical variables and BM

From: Development and validation of a nomogram model based on blood-based genomic mutation signature for predicting the risk of brain metastases in non-small cell lung cancer

Characteristic

No-BM

(N = 321)

BM

(N = 74)

Total

(N = 395)

BMI, kg/m2

 Mean (SD)

22.4 (3.13)

21.7 (3.02)

22.2 (3.11)

Gender

 Female

137 (42.7%)

36 (48.6%)

173 (43.8%)

 Male

184 (57.3%)

38 (51.4%)

222 (56.2%)

Age, y

 Mean (SD)

59.1 (10.8)

59.5 (8.90)

59.2 (10.4)

Histology

 Adenocarcinoma

248 (77.3%)

67 (90.5%)

315 (79.7%)

 Squamous

67 (20.9%)

5 (6.8%)

72 (18.2%)

 Other

6 (1.9%)

2 (2.7%)

8 (2.0%)

Ki67

 Median [Min, Max]

0.200 [0.0100, 0.900]

0.300 [0.0500, 0.800]

0.200 [0.0100, 0.900]

T

 Tis/1

166 (51.7%)

23 (31.1%)

189 (47.8%)

 T2

88 (27.4%)

23 (31.1%)

111 (28.1%)

 T3

22 (6.9%)

7 (9.5%)

29 (7.3%)

 T4

45 (14.0%)

21 (28.4%)

66 (16.7%)

N

 N0

202 (62.9%)

19 (25.7%)

221 (55.9%)

 N1

22 (6.9%)

4 (5.4%)

26 (6.6%)

 N2

51 (15.9%)

22 (29.7%)

73 (18.5%)

 N3

46 (14.3%)

29 (39.2%)

75 (19.0%)

Stage

 I

167 (52.0%)

0 (0%)

167 (42.3%)

 II

27 (8.4%)

0 (0%)

27 (6.8%)

 III

58 (18.1%)

0 (0%)

58 (14.7%)

 IV

69 (21.5%)

74 (100%)

143 (36.2%)

Chemotherapy

 No

185 (57.6%)

40 (54.1%)

225 (57.0%)

 Yes

136 (42.4%)

34 (45.9%)

170 (43.0%)

CEA

 < 5 ng/ml

227 (70.7%)

19 (25.7%)

246 (62.3%)

 ≥ 5 ng/ml

94 (29.3%)

55 (74.3%)

149 (37.7%)

NLR

 Low

128 (39.9%)

54 (73.0%)

182 (46.1%)

 High

193 (60.1%)

20 (27.0%)

213 (53.9%)

PLR

 Low

115 (35.8%)

42 (56.8%)

157 (39.7%)

 High

206 (64.2%)

32 (43.2%)

238 (60.3%)

AAPR

 Low

78 (24.3%)

31 (41.9%)

109 (27.6%)

 High

243 (75.7%)

43 (58.1%)

286 (72.4%)

LMR

 Low

148 (46.1%)

11 (14.9%)

159 (40.3%)

 High

173 (53.9%)

63 (85.1%)

236 (59.7%)

  1. Abbreviations: BMI Body Mass Index, NLR Neutrophil to lymphocyte ratio, PLR Platelet to lymphocyte rate, AAPR Albumin to alkaline phosphatase ratio, LMR Lymphocyte-to-monocyte ratio