Integrating genetic and clinical data to predict lung cancer in patients with chronic obstructive pulmonary disease

Table 4 Genetic association analysis of rs1489759 and rs56113850

SNPs	Genotype	COPD + LC vs. COPD			COPD + LC vs. LC only
SNPs	Genotype	OR	95%CI	P	OR	95%CI	P
rs1489759	GA-AA vs. GG	1.174	0.528–2.612	0.693	1.146	0.507–2.589	0.744
	AA vs. GG-GA	1.793	1.166–2.756	0.008	0.843	0.550–1.293	0.435
	AA vs. GA vs. GG	1.503	1.063–2.125	0.021	0.919	0.653–1.292	0.627
rs56113850	TC-CC vs. TT	2.431	1.514–3.903	< 0.001	3.871	2.409–6.218	< 0.001
	CC vs. TT-TC	1.722	1.067–2.781	0.026	3.470	1.965–6.128	< 0.001
	CC vs. TC vs. TT	1.677	1.258–2.236	< 0.001	2.602	1.893–3.577	< 0.001

SNPs: single nucleotide polymorphisms; COPD: chronic obstructive pulmonary disease; LC: lung cancer; OR: odds ratio; CI: confidence interval

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