Skip to main content

Table 3 Meta-analysis of subgroup analysis

From: The prognostic impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on patients with small cell lung cancer receiving first-line platinum-based chemotherapy: a systematic review and meta-analysis

Indicator

Number of included studies

I2(%)

The model of meta-analysis

HR (95%CI)

P Value

NLR on OS in SCLC patients

     

 LS-SCLC

4

66.2

R

1.56 (1.15–2.16)

< 0.001

 ES-SCLC

3

16.8

F

1.51 (1.21–1.73)

< 0.001

 P-SCLC

9

56.6

R

1.41 (1.20–1.69)

< 0.001

 C-SCLC

2

0

F

1.46 (1.23–1.66)

< 0.001

 Asia

7

61.8

R

1.39 (1.13–1.81)

< 0.001

 Non-Asia

4

0

R

1.43 (1.32–1.61)

< 0.001

 NLR cutoff value ≥ 4

6

47.8

F

1.47 (1.31–1.63)

< 0.001

 NLR cutoff value < 4

5

71.1

R

1.39 (0.99–1.97)

0.065

PLR on OS in SCLC patients

     

 LS-SCLC

2

0

F

1.63 (1.26–2.12)

0.091

 ES-SCLC

3

81.1

R

1.16 (0.79–1.71)

0.361

 PLR cutoff value ≥ 160

3

56.1

R

0.95 (0.76–1.22)

0.551

 PLR cutoff value < 160

2

5

7

1.76 (1.26–2.21)

< 0.001

  1. NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; LS-SCLC: limited-stage small-cell lung cancer; ES-SCLC: extensive-stage small-cell lung cancer, R: random-effects model; F: fixed-effects model; P-SCLC: pure- small-cell lung cancer; C-SCLC: combined small-cell lung cancer;