Table 2 Relative serum protein levels in differentially expressed proteins among men and women with SSc-ILD
Protein full name | Protein symbol | Fold difference in mean protein value in women relative to men | Two-sided p value |
|---|---|---|---|
Azurocidin | AZU1 | 0.39 | 0.008 |
Plastin 1 | PLS1 | 0.45 | 0.011 |
Bisphosphoglycerate mutase | BPGM | 0.48 | 0.024 |
Heat shock protein family A (Hsp70) member 8 | HSPA8 | 0.48 | 0.026 |
Phosphogluconate Dehydrogenase | PGD | 0.49 | 0.038 |
Histone H4 | HIST4H4 | 0.51 | 0.018 |
Cathepsin G | CTSG | 0.53 | 0.015 |
Coronin-1 A | CORO1A | 0.57 | 0.023 |
Desmocollin-3 | DSC3 | 0.59 | 0.049 |
Immunoglobulin Heavy Variable 2-70D | IGHV2-70D | 0.60 | 0.047 |
Brain abundant membrane attached signal protein 1 | BASP1 | 0.60 | 0.007 |
Transaldolase 1 | TALDO1 | 0.61 | 0.045 |
Insulin like growth factor binding protein 7 | IGFBP7 | 0.61 | 0.009 |
Immunoglobulin heavy variable 1–8 | IGHV1-8 | 0.61 | 0.025 |
Leukotriene A4 Hydrolase | LTA4H | 0.62 | 0.008 |
Phosphatidylethanolamine Binding Protein 4 | PEBP4 | 0.67 | 0.044 |
Protein C receptor | PROCR | 0.70 | 0.015 |
Lipocalin 2 | LCN2 | 0.74 | 0.049 |
TIMP metallopeptidase inhibitor 1 | TIMP1 | 0.74 | 0.039 |
Protein Tyrosine Phosphatase Receptor Type G | PTPRG | 0.80 | 0.038 |
Insulin-like growth factor 2 receptor | IGF2R | 0.81 | 0.045 |
selenoprotein P | SELENOP | 0.88 | 0.039 |
Complement 5 | C5 | 0.95 | 0.043 |
Fibronectin 1 | FN1 | 1.13 | 0.047 |
apolipoprotein E | APOE | 1.14 | 0.032 |
Hepatocyte growth factor activator | HGFAC | 1.15 | 0.020 |
Insulin-like growth factor (IGF) binding protein-3 | IGFBP3 | 1.20 | 0.035 |
Insulin-like growth factor 2 | IGF2 | 1.21 | 0.028 |
Protein tyrosine phosphatase receptor type J | PTPRJ | 1.25 | 0.042 |
Lysosomal associated membrane protein 1 | LAMP1 | 1.25 | 0.026 |
Angiopoietin-like 3 | ANGPTL3 | 1.31 | 0.014 |
Immunoglobulin Heavy Variable 2–5 | IGHV2-5 | 1.41 | 0.049 |
Carnosine Dipeptidase 1 | CNDP1 | 1.42 | 0.008 |
Contactin 1 | CNTN1 | 1.46 | 0.010 |
Serpin Family A Member 11 | SERPINA11 | 1.57 | 0.001 |
Fibrinogen-Like Protein 2 | FGL2 | 1.59 | 0.035 |
Ectonucleotide Pyrophosphatase/ Phosphodiesterase 2 | ENPP2 | 1.75 | 0.000005 |
immunoglobulin heavy variable 4-38-2 | IGHV4-38-2 | 2.00 | 0.037 |
Immunoglobulin Heavy Variable 1-69D | IGHV1-69D | 2.07 | 0.027 |
DEAD-Box Helicase 46 | DDX46 | 2.98 | 0.009 |