Table 1 Clinical characteristics of CAP and CAP-T2DM patients
Variables | CAP n = 540 | CAP-T2DM N = 180 | p value |
|---|---|---|---|
Gender (male %) | 341 (63.1) | 111 (61.7) | 0.723 |
Age (years) | 72.00 (62.00, 79.00) | 72.00 (63.00, 78.00) | 0.587 |
Comorbidities, n (%) | |||
 Hypertension | 191 (35.4) | 67 (37.2) | 0.655 |
 Chronic Cardiovascular Diseases | 127 (23.5) | 44 (24.4) | 0.840 |
 Chronic Pulmonary Diseases | 51 ( 9.4) | 21 (11.7) | 0.391 |
 Chronic Cerebrovascular Diseases | 83 (15.4) | 31 (17.2) | 0.557 |
 Chronic Hepatic Diseases | 12 ( 2.2) | 6 ( 3.3) | 0.413 |
 Chronic Renal Diseases | 17 ( 3.1) | 7 ( 3.9) | 0.634 |
 Cancer | 27 ( 5.0) | 11 ( 6.1) | 0.566 |
Complete blood count | |||
 WBC (× 109/L) | 7.80 (5.80, 11.70) | 8.90 (6.50, 13.02) | 0.006 |
 NEU (× 109/L) | 6.15 (4.10, 10.01) | 7.12 (4.92, 10.79) | 0.007 |
 LYM (× 109/L) | 0.94 (0.60, 1.40) | 1.21 (0.71, 1.76) | 0.001 |
 PLT (× 109/L) | 180.00 (130.00, 252.00) | 186.50 (135.00, 251.75) | 0.364 |
 HB (g/L) | 120.00 (106.00, 131.50) | 117.00 (101.00, 133.00) | 0.376 |
 NLR | 6.66 (3.33, 13.71) | 6.40 (3.73, 11.87) | 0.776 |
 PLR | 200.23 (121.28, 323.08) | 162.18 (104.29, 294.09) | 0.022 |
Infection and inflammation | |||
 ESR (mm/h) | 45.00 (21.00, 72.50) | 56.00 (27.00, 89.50) | 0.059 |
 PCT (ug/L) | 0.17 (0.10, 0.84) | 0.18 (0.10, 0.83) | 0.470 |
 CRP (mg/L) | 36.74 (8.96, 104.38) | 37.03 (8.00, 110.82) | 0.947 |
Blood glucose condition | |||
 GLU (mmol/L) | 5.77 (5.02, 7.09) | 10.33 (7.24, 14.99) | < 0.001 |
 HbA1c (%) | 5.90 (5.60, 6.30) | 7.80 (6.80, 10.30) | < 0.001 |
Coagulation | |||
 APTT (sec) | 36.70 (32.30, 40.80) | 34.75 (31.30, 39.30) | 0.010 |
 FIB (g/L) | 4.26 (3.26, 5.79) | 4.42 (3.39, 5.79) | 0.272 |
 PT (sec) | 13.70 (12.90, 14.70) | 13.80 (12.90, 14.60) | 0.861 |
 INR | 1.08 (1.02, 1.17) | 1.09 (1.01, 1.17) | 0.705 |
 TT (sec) | 17.55 (16.70, 18.72) | 17.60 (16.80, 18.70) | 0.615 |
Renal function | |||
 BUN (mmol/L) | 5.76 (4.31, 8.10) | 5.78 (4.44, 8.87) | 0.507 |
 CREA (umol/L) | 73.35 (59.00, 92.55) | 71.70 (54.92, 97.53) | 0.296 |
 UA (umol/L) | 300.30 (229.00, 383.50) | 292.60 (228.25, 376.70) | 0.916 |
 A1MG (mg/L) | 26.90 (21.50, 36.58) | 31.60 (22.10, 43.55) | 0.235 |
 B2MG (mg/L) | 2.70 (1.86, 4.65) | 2.69 (1.92, 4.11) | 0.872 |
 Ca (mmol/L) | 2.17 (2.07, 2.28) | 2.20 (2.07, 2.31) | 0.092 |
 Cl (mmol/L) | 105.80 (103.00, 108.10) | 105.00 (101.50, 108.10) | 0.187 |
 K (mmol/L) | 3.84 (3.48, 4.19) | 3.94 (3.60, 4.25) | 0.049 |
 Mg (mmol/L) | 0.87 (0.80, 0.94) | 0.86 (0.78, 0.93) | 0.118 |
 Na (mmol/L) | 139.10 (136.35, 141.80) | 139.00 (136.00, 142.00) | 0.955 |
 P (mmol/L) | 0.97 (0.83, 1.16) | 0.96 (0.82, 1.13) | 0.615 |
Liver function | |||
 ALT (U/L) | 18.00 (11.00, 33.00) | 18.00 (12.00, 30.00) | 0.909 |
 AST (U/L) | 25.00 (19.00, 38.00) | 21.00 (15.00, 35.75) | 0.001 |
 AST/ALT | 1.42 (1.06, 2.00) | 1.22 (0.94, 1.62) | 0.001 |
 5’-NT (U/L) | 5.10 (3.20, 8.05) | 5.85 (3.30, 10.40) | 0.043 |
 ADA (U/L) | 11.90 (9.30, 16.00) | 15.30 (12.12, 20.20) | < 0.001 |
 ALP (U/L) | 84.00 (69.50, 106.00) | 96.50 (75.25, 128.00) | 0.001 |
 CHE (U/L) | 5712.00 (4442.00, 7104.50) | 6035.00 (4968.75, 7816.25) | 0.011 |
 GGT (U/L) | 26.00 (17.00, 56.00) | 34.00 (21.25, 64.00) | 0.019 |
 LDH (U/L) | 220.00 (185.00, 288.75) | 217.50 (174.00, 291.50) | 0.237 |
 MAO (U/L) | 10.40 (7.90, 14.90) | 10.10 (7.18, 14.40) | 0.443 |
 TP (g/L) | 64.90 (59.90, 69.88) | 65.05 (59.73, 70.70) | 0.614 |
 PA (mg/L) | 152.00 (109.50, 195.00) | 152.00 (109.75, 195.00) | 0.608 |
 ALB (g/L) | 35.00 (31.20, 38.50) | 34.30 (30.50, 38.55) | 0.487 |
 GLOB (g/L) | 29.35 (25.80, 32.90) | 29.90 (26.20, 33.98) | 0.174 |
 A/G | 1.20 (1.00, 1.40) | 1.20 (1.00, 1.40) | 0.119 |
 TBA (umol/L) | 4.30 (2.30, 7.40) | 3.55 (2.20, 6.80) | 0.307 |
 CG (mg/L) | 1.70 (1.20, 2.73) | 1.85 (1.30, 2.40) | 0.618 |
 TBIL (umol/L) | 11.20 (8.00, 16.10) | 11.10 (6.93, 15.88) | 0.470 |
 DBIL (umol/L) | 3.40 (2.50, 5.70) | 3.40 (2.30, 5.40) | 0.394 |
Cardiac and myocardial condition | |||
 NT-proBNP (pg/ml) | 851.05 (226.22, 2554.76) | 803.60 (210.90, 2891.38) | 0.752 |
 CK-MB (U/L) | 1.51 (0.99, 2.80) | 1.46 (0.90, 2.63) | 0.458 |
 Mb (ng/ml) | 78.46 (44.63, 176.20) | 79.39 (52.38, 170.28) | 0.851 |
 cTnI (μg/L) | 0.02 (0.00, 0.05) | 0.02 (0.00, 0.06) | 0.558 |
 CK (U/L) | 95.00 (56.00, 211.00) | 81.00 (45.00, 133.50) | 0.023 |
 IMA (U/mL) | 80.30 (77.00, 85.70) | 80.70 (76.75, 84.35) | 0.675 |
CURB-65 score, n (%) | |||
 0–1 | 270 (50.2) | 90 (50.0) | 1.000 |
 2 | 185 (34.4) | 58 (32.2) | 0.649 |
 3–5 | 83 (15.4) | 32 (17.8) | 0.482 |
CURB-65 (points) | 1.00 (1.00, 2.00) | 1.50 (1.00, 2.00) | 0.770 |
LOS (days) | 6.00 (4.00, 10.00) | 9.00 (6.00, 13.25) | < 0.001 |