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Table 3 Association between NLR changes (0–14 days) and short-term mortality in patients with anti-MDA5 positive DM-ILD using a GAMM

From: Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study

 

Model 1

Model 2

Model 3

30-day mortality

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

Day

0.03 (−1.06,0.23)

0.770

0.03 (0.16,0.22)

0.780

0.03 (−0.17,0.23)

0.800

Death

4.02 (1.40,6.63)

0.003

3.88 (1.17,6.59)

0.005

4.59 (1.61,7.58)

0.003

Day × death

1.01 (0.73,1.29)

 < 0.001

1.01 (0.73,1.29)

 < 0.001

1.03 (0.75,1.31)

 < 0.001

  1. Time, the mean daily increase in NLR over time (1–14 days) in the survival group; death, the mean difference in NLR between the survivor and non-survivor groups at admission; death × day, daily rise in NLR, specifically within the non-survivor group compared with the survivor group
  2. Model 1, not adjusted for any variables. Model 2, adjusted for age and sex. Model 3, adjusted for age, sex, duration, smoking, mechanic’s hand, heliotrope rash, Gottron’s sign/papules, V sign, Shawl sign, periungual erythema, Raynaud phenomenon, skin ulcer, muscle weakness, arthritis, Ro52, fever, ANA, RA, ALB, ALT, AST, CK, LDH, CRP, ESR, and WBC count
  3. Abbreviations: ALB albumin, ALT alanine aminotransferase, ANA antinuclear antibody, AST aspartate aminotransferase, CI confidence interval, CK creatine kinase, CRP C-reactive protein, DM-ILD dermatomyositis with interstitial lung disease, ESR erythrocyte sedimentation rate, GAMM Generalized Additive Mixed Model, HR hazard ratio, LDH lactate dehydrogenase, NLR neutrophil-to-lymphocyte ratio, RA rheumatoid arthritis, WBC white blood cell count