Table 2 Summary of genetically proxied lipid-lowering drug targets
Therapies | Drug target | Encoding genes | Gene location (GRCh37 from Homo sapiens) | Gene ID | Eligible IVs | |
|---|---|---|---|---|---|---|
CHR | BP | |||||
↓LDL-C | ATP citrate lyase | ACLY | 17 | 40,023,170–40075275 | 47 | No |
apolipoprotein B | APOB | 2 | 21,224,301–21266945 | 338 | Yes | |
cholesteryl ester transfer protein | CETP | 16 | 56,995,862–57,017,757 | 1071 | No | |
3-hydroxy-3-methylglutaryl-CoA reductase | HMGCR | 5 | 74,632,993–74,657,941 | 3156 | No | |
low density lipoprotein receptor | LDLR | 19 | 11,200,139–11244496 | 3949 | Yes | |
NPC1 like intracellular cholesterol transporter 1 | NPC1L1 | 7 | 44,552,134–44,580,929 | 29,881 | No | |
proprotein convertase subtilisin/kexin type 9 | PCSK9 | 1 | 55,505,221–55530525 | 255,738 | Yes | |
↓TG | angiopoietin like 3 | ANGPTL3 | 1 | 63,063,191–63071984 | 27,329 | Yes |
apolipoprotein C3 | APOC3 | 11 | 116,700,623–116703788 | 345 | Yes | |
peroxisome proliferator activated receptor alpha | PPARA | 22 | 46,546,429–46,639,653 | 5465 | No | |