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Table 4 Predictors of significant CAD identified by CCTA

From: Incidence and clinical impact of coronary artery disease confirmed by coronary CT angiography in patients with interstitial lung disease

Variables

Univariate analysis

Multivariable analysis

OR (95% Cl)

P-Value

OR (95% Cl)

P-Value

Age*

1.08 (1.04 − 1.11)

< 0.001

1.05 (1.01 − 1.09)

0.011

Male sex

2.37 (1.28 − 4.55)

0.007

1.97 (0.72 − 5.45)

0.186

Body mass index*

0.98 (0.89 − 1.07)

0.624

  

Smoking history

1.85 (1.05 − 3.29)

0.034

1.17 (0.48 − 2.88)

0.730

IPF

1.51 (0.87 − 2.63)

0.144

1.13 (0.57 − 2.24)

0.724

Hypertension

2.78 (1.60 − 4.91)

< 0.001

2.00 (1.02 − 3.93)

0.043

Diabetes

1.57 (0.90 − 2.78)

0.115

0.84 (0.42 − 1.66)

0.612

FVC*

0.99 (0.98 − 1.01)

0.468

  

DLco*

1.01 (0.99 − 1.02)

0.434

  

TWI on ECG

1.86 (0.91 − 3.88)

0.093

2.01 (0.88 − 4.70)

0.101

LV ejection fraction*

1.03 (0.99 − 1.09)

0.197

1.05 (1.00 − 1.11)

0.063

Coronary calcification†

2.58 (1.48 − 4.54)

< 0.001

2.26 (1.13 − 4.58)

0.022

  1. *Odds ratios for CAD identified by CCTA were calculated by dichotomizing age at 63 years, BMI at 25 kg/m², FVC at 0.8, DLCO at 0.6, and LVEF at 40%. Analysis parameters with statistically significant differences are shown in bold
  2. †This refers to coronary calcification identified by visual estimation on non-gated chest CT
  3. CAD = coronary artery disease; CCTA = coronary computed tomography angiography; CI = confidential interval; DLco = diffusing capacity for carbon monoxide; ECG = electrocardiogram; LV = left ventricle; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; OR = odds ratio
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BMC Pulmonary Medicine

ISSN: 1471-2466

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