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Table 3 Characteristics of non-pulmonary organ dysfunction in ARDS patients with or without malignancy

From: Comparing the clinical characteristics and risk factors of prognosis in pediatric ARDS with and without malignancies: a retrospective cohort study

Characteristic

Malignancy (n = 60)

Non-malignancy (n = 128)

P

Total

Survivors (n = 27)

Non-survivors (n = 33)

P

Total

Survivors (n = 88)

Non-survivors (n = 40)

P

Total pSOFA score

14.0 (12.0–15.0)

12.0 (10.0–14.0)

15.0 (14.0–16.0)

<0.01

9.0 (8.0–11.0)

8.0 (7.0–10.0)

11.0 (9.0–13.0)

<0.01

<0.01

Nervous system

         

pSOFA score > 0

50.0 (83.0)

22.0 (81.0)

28.0 (85.0)

0.728

115.0 (90.0)

77.0 (88.0)

38.0 (95.0)

0.193

0.204

Cardio Vascular system

        

pSOFA score > 0

57.0 (95.0)

24.0 (89.0)

33.0 (100.0)

0.085

117.0 (91.0)

79.0 (90.0)

38.0 (95.0)

0.524

0.564

VIS at peak

73.0 (20–208)

35.0 (10.0–80.0)

180.0 (45.0-338.0)

<0.01

15.0 (5.0–82.0)

10.0 (5.0–39.0)

79.0 (10.0-195.0)

<0.01

<0.01

Renal

         

pSOFA score > 0

22.0 (37.0)

7.0 (26.0)

15.0 (76.0)

0.118

28.0 (22.0)

16.0 (18.0)

12.0 (30.0)

0.134

0.032

Hematologic

         

pSOFA score > 0

54.0 (90.0)

23.0 (85.0)

31.0 (94.0)

0.489

30.0 (23.0)

17.0 (19.3)

13.0 (32.5)

0.103

<0.001

Absolute neutrophil count (× 103/µL)

0.37 (0.04–1.18)

0.37 (0.04–1.7)

0.3 (0.04–0.93)

0.618

5.34 (2.85–9.2)

4.57 (2.73–8.22)

7.12 (3.25-11.00)

0.068

<0.001

Haematoglobin

70.0 (55.0–82.0)

69.0 (58.0–87.0)

70.0 (55.0–80.0)

0.414

90.0 (76.0-106.0)

92.0 (78.0-108.0)

84.0 (62.0–98.0)

0.057

0.001

Transfusion of Red Blood

52.0 (87.0)

22.0 (81.0)

30.0 (91.0)

0.448

62.0 (48.0)

39.0 (44.0)

23.0 (58.0)

0.167

0.028

Absolute Platelet counts (× 109/µL)

17.0 (8.0–73.0)

21.0 (10.0-110.0)

16.0 (8.0–43.0)

0.252

232.0 (152.0-330.0)

246.0 (167.0-335.0)

206.0 (103.0-309.0)

0.057

0.001

Transfusion of Platelet

44.0 (73.0)

17.0 (63.0)

27.0 (82.0)

0.100

18.0 (14.0)

10.0 (11.0)

8.0 (20.0)

0.193

<0.001

Liver

         

pSOFA score > 0

37.0 (62.0)

16.0 (59.0)

21.0 (64.0)

0.729

24.0 (19.0)

14.0 (16.0)

10.0 (25.0)

0.222

<0.001

Lactate

1.5 (0.8–3.7)

1.2 (0.7-2.0)

2.7 (1.1–6.3)

0.006

1.0 (0.7-2.0)

0.9 (0.7–1.6)

1.6 (0.7–2.9)

0.02

0.008

Infection

         

CRP

150.0 (83.0-168.0)

113.0 (78.0-160.0)

160.0 (100.0-170.0)

0.096

31.0 (10.0-108.0)

22.5 (9.3–98.8)

84.0 (10.0-170.0)

0.02

<0.001

PCT

10.4 (2.0-27.5)

3.5 (2.1–15.8)

16.6 (2.4–32.7)

0.193

1.2 (0.3–6.2)

0.9 (0.3–5.1)

2.8 (0.4–11.5)

0.052

<0.001

Cytokines

         

IFN-γ

26.9 (9.1–146.0)

17.5 (7.3-182.9)

27.1 (8.0-115.3)

0.927

11.9 (4.9–55)

11.8 (4.6–41.3)

26.5 (5.2–62.3)

0.364

0.198

IL-6

206.3 (21.6-1257.8)

210.4 (17.5-598.1)

202.1 (44.4-7421.5)

0.371

99.6 (33.7-266.9)

96.2 (28.5-203.8)

109.4 (63-704.5)

0.032

0.205

IL-8

325.8 (9.0-1119.0)

84.7 (6.7-507.2)

540.1 (11.4-4449.5)

0.181

43.0 (18-103.8)

36.9 (19.0–96.0)

50.5 (16.1-159.4)

0.889

0.082

TNF-α

4.0 (2.0–10.0)

3.3 (2.4–10.2)

3.8 (1.9–9.5)

0.935

3.6 (2.4–8.2)

3.9 (2.4-8.0)

3.3 (2.4–11)

0.654

0.926

Cellular immunity

        

CD4 + T

26.9 (18.5–37.2)

25.9 (19.2–37.9)

27.9 (16.4–37.9)

0.935

26.6 (20.0-35.2)

25.1 (17.2–27.8)

30.3 (21.6–39.5)

0.141

0.870

CD8 + T

36.9 (26.0-53.6)

41.6 (32.9–65.4)

35.9 (21.9–41.3)

0.113

21.9 (17.3–29.1)

21.4 (17.2–27.8)

26.3 (16.9–34.3)

0.202

<0.001

CD19 + T

9.9 (0.9–30.2)

6.1 (0.6–20.3)

18 (3.4–35.2)

0.173

33.6 (22-46.6)

34.6 (25.3–47.1)

27.4 (13.9–41.1)

0.055

<0.001

NK

4.0 (2.0–10.0)

3.7 (1.5–10.3)

4.9 (1.8–9.9)

0.705

5.6 (2.7-9.0)

5.6 (3.2–9.1)

5.0 (1.7–9.3)

0.210

0.210

  1. Abbreviations: CRP, C-reactive protein (mg/L); PCT, procalcitonin (mg/L); Lactate, Lactic acid (mmol/L); IFN-γ, interferon-γ (pg/mL); IL-6, interlukin-6 (pg/mL); IL-8, interlukin-8 (pg/mL); TNF-α, Tumor Necrosis Factor-alpha (pg/mL)
  2. The missing values were imputed with the median of available data points for each variable. The values were taken the worst within 48 h after being diagnosed with ARDS
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BMC Pulmonary Medicine

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