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Table 2 Factors associated with never-smokers compared to ever-smokers among patients with COPD

From: Distinct risks of exacerbation and lung function decline between never-smokers and ever-smokers with COPD

Variable

Univariable

Multivariable

OR (95% CI)

P-value

aOR (95% CI)*

P-value

Female sex

29.7 (15.3–57.5)

< 0.001

15.4 (6.81–34.9)

< 0.001

History of tuberculosis

2.49 (1.51–4.1)

< 0.001

1.25 (0.59–2.57)

0.551

Physician-diagnosed asthma

1.85 (1.11–3.07)

0.019

1.50 (0.71–2.97)

0.269

FVC % predicted

0.97 (0.96–0.99)

< 0.001

0.99 (0.41–1.05)

0.199

Positive bronchodilator response

0.09 (0.01–0.64)

0.016

0.12 (0.02–0.98)

0.047

Absence of emphysema

15.9 (8.69–29.2)

< 0.001

9.01 (0.05–0.21)

< 0.001

Tuberculosis-destroyed lung

3.60 (1.94–6.68)

< 0.001

4.14 (1.56–11.2)

0.005

Bronchiectasis

2.82 (1.68–4.75)

< 0.001

1.86 (0.89–3.87)

0.099

  1. *Adjusted for all variables used in the univariable analysis
  2. OR = odds ratio; aOR = adjusted odds ratio; CI = confidence interval; FVC = forced vital capacity