Table 1 Comparison of histopathological findings between groups according to GGP
From: The effect of bempedoic acid on histopathologic changes associated with natural aging in rat lungs
YC | YD | EC | ED | P | |
|---|---|---|---|---|---|
Alveolar acidophilic macrophage pneumonia | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 |
Alveolar histiocytosis | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 |
Foamy cells | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 |
Heart failure cell | 0 (0–1) | 0 (0–0) | 0 (0–0,25) | 1 (0–2,25) | 0,024 |
Interstitial pneumonia | 2 (1,75 − 3) | 2 (2–3) | 2 (2–2,25) | 1,5 (1–2) | 0,1 |
Perivascular inflammation | 1(1–1,25) | 1 (1–2) | 2 (1,75 − 3) | 2 (1–2) | 0,019 |
Bronchial/bronchiolar inflammation | 2 (2–3) | 2 (1–3) | 2 (1,75 − 3) | 2,5 (1,75 − 3) | 0,95 |
Airway metaplasia and hyperplasia | 1 (1–1) | 1 (1–1,25) | 1,5 (1–2) | 1 (1–1) | 0,036 |
Vascular hypertrophy | 1 (0,75 − 2) | 1 (1–3) | 1 (0–2) | 1 (0–1,25) | 0,29 |
Pulmonary fibrosis | 1 (1–2) | 1,5 (1–2) | 1 (1–1,25) | 1 (1–2) | 0,79 |
Atelectasis | 0 (0–0) | 0 (0–0,25) | 0 (0–0) | 1 (0–1) | 0,017 |
Lymphoid aggregates | 2 (2–3) | 1 (1–3) | 1,5 (1–3) | 2,5 (1,75 − 3) | 0,31 |
Tumor | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 |
Composite lesion score | 10,5 (9–15,5) | 11 (8,75 − 16,5) | 12,5 (11–15) | 13,5 (11,25 − 15,25) | 0,704 |