Fig. 4

KEGG Pathway Enrichment Analysis of m6A-modified circRNAs. The Sankey diagram represents the enriched KEGG pathways linked to differentially expressed m6A-modified circRNAs in the OSA-induced cardiac injury model. The pathways shown, such as the AMPK signaling pathway, focal adhesion, and proteoglycans in cancer, are among the top 10 enriched pathways with a significant involvement in myocardial injury. Each pathway is annotated with the associated genes, including CTNNA1, FLNB, and HIF1A, which play a crucial role in cardiac pathophysiology. The diagram also shows the ratio of differentially expressed genes (DE genes) to the total number of genes in each pathway, providing a visual summary of the functional roles of these circRNAs in OSA-induced cardiovascular damage. Color-coded pathways highlight the strength of enrichment, with red indicating pathways most significantly affected by the circRNAs