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Table 1 Demographic, clinical, mechanical ventilation characteristics the first day of ARDS, support used in the ICU, and mortality stratified by obesity

From: Association of obesity on short- and long-term survival in patients with moderate to severe pneumonia-related ARDS: a retrospective cohort study

 

All patients (n = 603)

Patients without obesity (n = 376)

Patients with obesity (n = 227)

P Value

Age, years

62 (52,71)

63 (52, 72)

61 (50,69)

0.054

Male gender, n (%)

404 (67)

267 (71)

137 (60)

0.009

SAPS II score, points

43 (32,58)

43 (33, 59)

41 (32,56.25)

0.24

SOFA score, points

7 (5,10)

8 (5, 10)

7 (5,10)

0.09

BMI, kg.m−2

27.4 (23.9, 28.8)

24.79 (22.4, 27.1)

33.98 (31.9,38.1)

 < 0.001

Hypertension, n (%)

227 (37)

116 (31)

111 (49)

 < 0.001

Diabetes mellitus, n (%)

91 (15)

30 (8)

61 (27)

 < 0.001

Atrial fibrillation, n (%)

51 (9)

28 (7)

23 (10)

0.32

Coronary artery disease, n (%)

58 (10)

35 (9)

23 (10)

0.85

COPD, n (%)

133 (22)

93 (25)

40 (18)

0.05

Immunosupression, n (%)

113 (19)

82 (22)

31 (14)

0.02

Influenza*, n (%)

91 (15)

58 (15)

33 (14)

0.86

Covid-19*, n (%)

259 (43)

149 (40)

110 (48)

0.04

Bacteria involved in pneumonia*, n (%)

212 (35)

135 (36)

57 (25)

0.008

Pneumocystosis, n (%)

41 (7)

29 (8)

12 (5)

0.32

Acute kidney injury, n (%)

141 (23)

83 (22)

58 (26)

0.38

PaO2/FiO2 ≤ 100 mmHg, n (%)

339 (60)

194 (52)

145 (64)

0.006

PaCO2 ≥ 50 mmHg, n (%)

324 (54)

213 (57)

111 (49)

0.08

Vt/PBW, ml/kg

6.24 (5.98,6.59)

6.21 (5.96,6.50)

6.34 (6.04,6.75)

 < 0.001

Plateau pressure, cmH2O

25 (22,25)

25 (22,28)

23 (23,28)

0.24

PEEP, cmH2O

12 (10,12)

10 (8,12)

12 (10,14)

0.007

Ventilatory ratio

2.31 (1.89,2.86)

2.32 (1.85,2.88)

2.31 (1.94,2.81)

0.68

Prone positioning, n (%)

383 (63)

213 (56)

170 (75)

 < 0.001

Renal replacement, n (%)

131 (22)

80 (21)

51 (22)

0.81

ECMO, n (%)

46 (8)

26 ( 7)

19 ( 8)

0.73

Treatment with steroids the first week of ARDS, n (%)

442 (73)

274 (73)

168 (74)

0.72

Vasopressors, n (%)

513 (85)

328 (87)

185 (82)

0.07

Ventilator-free days at 28 days

7 (0,17)

6 (0,17)

9 (0,17)

0.39

Mortality at 28 days, n (%)

109 (19)

87 (23)

32 (14)

0.009

Mortality at 90 days, n (%)

177 (29)

124 (33)

53 (23)

0.015

Mortality at 1 year, n (%)

197 (33)

138 (36)

59 (26)

0.009

  1. Data are presented as median (interquartile range) for continuous measures
  2. ARDS Acute Respiratory Distress Syndrome, COPD Chronic Obstructive Pulmonary Disease, ECMO Extracorporeal Membrane Oxygenation, PEEP Positive End-Expiratory Pressure, PBW Predict Body Weight, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, Vt tidal volume
  3. *Involved in pneumonia, including mixed infections
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BMC Pulmonary Medicine

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