Lactate dehydrogenase to albumin ratio and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study

Table 2 Cox proportional hazard ratios (HRs) for all-cause mortality based on LAR

Log2 LAR	Unadjusted model		Model I		Model II		Model III
Log2 LAR	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
1-month mortality
Low LAR	Ref		Ref		Ref		Ref
Middle LAR	1.74 (1.16, 2.63)	0.008	1.65 (1.10, 2.49)	0.017	1.68 (1.11, 2.54)	0.015	1.74 (1.09, 2.77)	0.020
High LAR	2.58 (1.75, 3.80)	< 0.001	2.69 (1.82, 3.99)	< 0.001	2.67 (1.79, 3.98)	< 0.001	2.38 (1.45, 3.92)	< 0.001
3-month mortality
Low LAR	Ref		Ref		Ref		Ref
Middle LAR	1.54 (1.10, 2.16)	0.012	1.49 (1.06, 2.08)	0.022	1.51 (1.08, 2.13)	0.016	1.61 (1.09, 2.35)	0.015
High LAR	2.18 (1.58, 3.01)	< 0.001	2.26 (1.64, 3.12)	< 0.001	2.27 (1.63, 3.16)	< 0.001	2.20 (1.45, 3.33)	< 0.001

Crude model: we did not adjust other covariates. Model I: we adjusted age, gender and race. Model II: we adjusted age, gender, race, hypertension, diabetes, CAD, CHF, CKD, liver disease, malignancy and obesity. Model III: we adjusted age, gender, race, HR, RR, SBP, SpO2, hypertension, diabetes, CAD, CHF, CKD, liver disease, malignancy, obesity, serum sodium, serum potassium, glucose, BUN, Cr, WBC, HGB, PLT, use of ventilator/ noninvasive ventilator, SOFA, OASIS, SAPSII. AECOPD, acute exacerbation of chronic obstructive pulmonary disease; BUN, blood urea nitrogen; CAD, coronary atherosclerotic disease; WBC, white blood cells; CHF, congestive heart failure; CI, confidence interval; CKD, chronic renal failure; Cr, creatinine; HGB, hemoglobin; LAR, Lactate dehydrogenase to albumin ratio; OASIS, oxford acute severity of illness score; PLT, platelet; SAPSII, simplified acute physiology score II; SBP, systolic pressure; SOFA, sequential organ failure assessment; SpO2, blood oxygen saturation; Ref, reference

ISSN: 1471-2466