Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV1% ≥80% predicted

Table 2 Optimal cut-off values and other measures of usefulness for predicting bronchial hyperresponsiveness in suspected classic asthma patients with FEV₁% ≥ 80%

Characteristic variables	AUC	95% CI of AUC	Cut-off value^†	Sensitivity %	Specificity %	PPV %	NPV %	p value
FEV₁, %pred	0.621	0.572 to 0.669	≤ 98.8	54.95	66.5	62.4	59.4	< 0.0001
FEV₁/FVC, %	0.672	0.623 to 0.717	≤ 81.07	60.89	69	66.5	63.6	< 0.0001
PEF, %pred	0.631	0.582 to 0.678	≤ 109.83	74.75	45.5	58.1	64.1	< 0.0001
MEF75, %pred	0.688	0.641 to 0.733	≤ 94.6	54.46	76	69.6	62.3	< 0.0001
MEF50, %pred	0.734	0.688 to 0.776	≤ 76.2	58.42	77	72	64.7	< 0.0001
MEF25, %pred	0.652	0.603 to 0.698	≤ 64.1	62.38	64.5	64	62.9	< 0.0001
MMEF, %pred	0.715	0.668 to 0.758	≤ 78.8	74.26	60.5	65.5	69.9	< 0.0001
FENO, ppb	0.728	0.682 to 0.771	> 30	57.92	81.5	76	65.7	< 0.0001
EOS in blood, cell/µl	0.670	0.608 to 0.728	> 0.16	55.07	77.19	74.5	58.7	< 0.0001
EOS% in blood, %	0.673	0.611 to 0.730	> 2.8	50	80.7	75.8	57.1	< 0.0001

AUC, Area under the curve; PPV, Positive predictive values; NPV, Negative predictive values; 95% CI, 95% confidence interval of odds ratio; P value, the p value of the logistic regression test
The other abbreviations are as defined for Table 1
^†The cut-off points were selected by maximizing the sum of sensitivity and specificity
Bold font indicates AUC higher than 0.70

ISSN: 1471-2466