Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV1% ≥80% predicted

Table 3 Optimal cut-off values and other measures of usefulness for predicting bronchial hyperresponsiveness in chronic cough patients

Characteristic variables	AUC	95% CI of AUC	Cut-off value^†	Sensitivity %	Specificity %	PPV %	NPV %	p value
FEV₁%pred	0.638	0.596 to 0.678	≤ 97.86	52.16	71.43	65.6	58.8	< 0.0001
FEV₁/FVC, %	0.644	0.603 to 0.685	≤ 81.06	52.88	71.80	66.2	59.3	< 0.0001
PEF%pred	0.596	0.554 to 0.638	≤ 113.4	80.22	35.47	56.6	63.1	0.0001
MEF75%pred	0.669	0.627 to 0.708	≤ 94.2	50.36	74.81	67.6	59.1	< 0.0001
MEF50%pred	0.738	0.699 to 0.775	≤ 87.1	76.26	57.14	65.0	69.7	< 0.0001
MEF25%pred	0.657	0.615 to 0.697	≤ 69.8	69.42	54.14	61.3	62.9	< 0.0001
MMEF%pred	0.716	0.677 to 0.754	≤ 73.7	63.67	68.05	67.6	64.2	< 0.0001
FENO, ppb	0.603	0.560 to 0.644	> 27	43.88	78.95	68.5	57.4	< 0.0001
EOS in blood, cell/µl	0.612	0.557 to 0.666	> 0.07	76.02	45.03	61.0	62.4	0.0004
EOS% in blood, %	0.620	0.565 to 0.674	> 2.1	53.22	70.86	67.4	57.2	0.0001

The abbreviations are as defined for Tables 1 and 2
^†The cut-off points were selected by maximizing the sum of sensitivity and specificity. Bold font indicates AUC higher than 0.70

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