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Table 4 Demographic data, spirometric variables, FENO values, PD20 values, and peripheral eosinophils values of CA patients and CVA patients before ICS/LABA treatment

From: Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV1% ≥80% predicted

Variable

All subjects

CA

CVA

p value

(CA vs. CVA)

n

66

31

35

-

Age, years

42.56 [15.14]

39.32 [14.21]

45.43 [15.55]

0.123

Height, m

1.656 [0.0831]

1.67 [0.0796]

1.643 [0.0853]

0.172

Weight, kg

63.48 [13.10]

65.42 [12.31]

61.77 [13.71]

0.173

BMI, kg/m2

22.98 [3.354]

23.36 [3.393]

22.65 [3.333]

0.429

Symptom duration time, months

6 (6.25)

5 (8)

6 (6)

0.683

Symptom recovery time, days

7.5 (15.25)

7 (17)

8 (15)

0.738

ACT1

-

17 (2)

-

-

CET1

-

-

16 (3.0)

-

FENO, ppb

32.5 (29.5)

38 (24)

26 (34)

0.031

WBC, ×10^9/L

6.495 (2.335)

6.5 (2.49)

6.49 (2.08)

0.31

EOS in blood, cells/ul

0.13 (0.15)

0.14 (0.21)

0.11 (0.14)

0.137

EOS% in blood, %

1.7 (2.125)

1.9 (2.1)

1.4 (2)

0.292

FVC, L

3.395 (1.427)

3.52 (1.63)

3.22 (1.42)

0.061

FEV1, L

2.765 (1.14)

2.84 (1.29)

2.69 (1.12)

0.096

FEV1/FVC, %

81.28 [5.777]

80.77 [6.115]

81.73 [5.509]

0.724

PEF, L/s

6.46 (2.668)

6.47 (2.48)

6.45 (2.66)

0.857

MEF75, L/s

5.75 (2.267)

5.74 (2.35)

5.76 (1.97)

0.621

MEF50, L/s

3.065 (1.345)

3.32 (1.64)

3.06 (1.38)

0.175

MEF25, L/s

1.08 (0.908)

1.31 (0.96)

0.95 (0.71)

0.145

MMEF, L/s

2.535 (1.355)

2.68 (1.71)

2.37 (1.13)

0.117

FVC, %pred

98.32 (13.86)

98.4 (15.78)

97.38 (14.6)

0.787

FEV1, % pred

95.07 (12.56)

95.17 (13.51)

95.02 (13.67)

0.857

PEF, %pred

94.47 (21.75)

87.45 (15.84)

96.65 (24.14)

0.067

MEF75, %pred

90.34 (24.57)

88.92 (21.38)

90.71 (25.99)

0.594

MEF50, %pred

73.23 (27.04)

75.28 (27.29)

72.3 (27.24)

0.738

MEF25, %pred

61.22 (25.32)

61.94 (21.66)

58.76 (27.24)

0.452

MMEF, %pred

68.23 (26.77)

67.6 (23.81)

68.55 (24.43)

0.468

R5*, kPa·L-1·s

4.1 (1.8)

4.2 (2)

3.965 (1.298)

0.369

R5, %pred*

120.4 (49.9)

129.7 (52.4)

108 (41.74)

0.265

R20*, kPa·L-1·s

2.9 (0.8)

2.9 (0.87)

2.915 (1.263)

0.698

R20, %pred*

104.2 (28.14)

109.7 (28.84)

103.2 (29.23)

0.904

R5-R20*, kPa·L-1·s

0.9 (1.14)

1.0 (1.42)

0.575 (0.9025)

0.043

R5-R20, %pred*

11.69 (32.55)

13.39 (39.62)

3.87 (28.15)

0.059

ΔFVC, mL

55 (200)

30 (190)

70 (210)

0.407

ΔFEV1, mL

145 (160)

160 (160)

140 (140)

0.777

ΔPEF, mL/s

260 (890)

260 (750)

260 (920)

0.322

ΔMEF75, mL/s

355 (870)

360 (770)

350 (880)

0.594

ΔMEF50, mL/s

505 (630)

540 (520)

430 (830)

0.335

ΔMEF25, mL/s

265 (375)

290 (290)

260 (580)

0.422

ΔMMEF, mL/s

455 (395)

470 (280)

380 (820)

0.266

ΔFVC, %pred

1.535 (5.761)

0.64 (5.45)

1.66 (7.33)

0.342

ΔFEV1, %pred

5.75 (6.577)

5.26 (5.76)

6 (5.91)

0.332

ΔPEF, %pred

3.59 (13.99)

3.25 (11.35)

3.64 (15.72)

0.253

ΔMEF75, %pred

5.87 (14.40)

5.92 (14.13)

5.82 (14.2)

0.639

ΔMEF50, %pred

15.73 (19.54)

18.06 (18.34)

12.89 (22.4)

0.358

ΔMEF25, %pred

26.85 (34.30)

26.26 (23.71)

27.91 (72.62)

0.842

ΔMMEF, %pred

16.75 (18.75)

16.61 (14.56)

16.76 (26.23)

0.933

PD20, mg

0.1911 (0.3782)

0.2284 (0.3007)

0.1255 (0.4248)

0.559

  1. ACT, Asthma control test; VAS, Visual analogue scale; CET, Cough evaluation test; R5, Total airway resistance at 5 Hz; R20, Central airway resistance at 20 Hz; R5-R20, Peripheral airway resistance as the difference between 5 and 20 Hz; X5, Reactance at 5 Hz; %: the improvement of spirometric indices as a percentage of baseline value. ∆: increase of spirometric indices in BDT; ∆ %: the increase of spirometric indices as a percentage of baseline value in BDT
  2. The other abbreviations are as defined for Table 1
  3. Data expressed as Mean [SD] values and Median (IQR) values
  4. *n = 43 for all subjects, 31 for CA and 12 for CVA
  5. Bold font indicates statistical significance