Table 2 Comparisons between CAPA and non-CAPA patient

Male

206 (68.67%)

64 (70.32%)

142 (67.94%)

0.783

Age, years

75 (65–81)

76 (65–81)

74 (65–81)

0.215

BMI, kg/m2

23.3 (20.9–25.6)

22.8 (20.9–25.6)

23.4 (21.0-25.6)

0.278

Smoke

78 (26.00%)

27 (29.67%)

51 (24.40%)

0.416

Drink

54 (18.00%)

17 (18.68%)

37 (17.70%)

0.968

Underlying disease

Hypertension

168 (56.00%)

49 (53.84%)

119 (56.93%)

0.846

Diabetes

131 (43.67%)

51 (56.04%)

80 (38.27%)

0.006

Chronic respiratory diseases

34 (11.33%)

22 (24.17%)

12 (5.74%)

0.001

Chronic heart disease

37 (12.33%)

14 (15.38%)

23 (11.00%)

0.384

Chronic liver disesas

14 (46.67%)

10 (10.98%)

4 (1.91%)

0.002

Chronic renal insufficiency

53 (17.67%)

30 (32.96%)

23 (11.00%)

0.001

Immunosuppressive condition

94 (31.33%)

49 (53.84%)

45 (21.53%)

0.001

Solid Malignant Tumor

45 (15.00%)

26 (28.57%)

19 (9.09%)

0.001

Hematological malignancies

26 (8.67%)

11 (12.08%)

15 (7.17%)

0.243

Solid organ transplantation

16 (5.33%)

9 (9.89%)

7 (3.34%)

0.042

autoimmune disease

10 (3.33%)

4 (4.39%)

6 (2.87%)

0.744

Steroids in previous 60 days

19 (6.33%)

13 (14.28%)

6 (2.87%)

0.001

Immunosuppressants

18 (6.00%)

10 (10.98%)

8 (3.82%)

0.032

CT imaging

consolidation

50 (16.67%)

20 (21.97%)

30 (14.35%)

0.144

multiple interstitial exudation

130 (43.33%)

76 (83.51%)

149 (73.13%)

0.001

Pleural effusion

106 (35.33%)

28 (30.76%)

78 (38.83%)

0.337

Laboratory examination

Hemoglobin, g/L

114 (100–128)

113 (93–128) n = 91

115 (101–128) n = 201

0.378

Leukocyte count,10⁹/L

7.63 (5.06–10.83)

9.41 (6.15–13.18) n = 91

6.88 (4.79–9.60) n = 201

0.001

Neutrophils,10⁹/L

6.40 (3.98–9.32)

7.77 (5.28–11.93) n = 91

5.80 (3.72–8.38) n = 201

0.001

Lymphocytes,10⁹/L

0.57 (0.35–0.94)

0.47 (0.30–0.81) n = 91

0.62 (0.39–0.97) n = 201

0.516

platelet count,10⁹/L

169 (127–227)

169 (125–242) n = 91

169 (128–222) n = 201

0.813

APTT, s,

39.4 (35.8–46.6)

39 (33.7–45.8) n = 88

39.7 (36.5–46.9) n = 195

0.056

D-Dimer, mg/L,

1.36 (0.75–2.66)

1.96 (0.90–4.01) n = 88

1.21 (0.71–2.38) n = 195

0.115

ALT, U/L,

24.5(15.7–38.2)

25.0 (16.0–38.0) n = 89

23.0 (15.5–38.5) n = 199

0.111

AST, U/L,

34 (23–47)

30 (22–48) n = 89

34 (24–46) n = 199

0.148

TBIL,µmol/L

10 (8–14)

10 (8–14) n = 89

10 (8–13) n = 199

0.635

ALB, g/L

30.5 (27.8–33.6)

29.1(27.0-31.6) n = 91

31.4 (28.3–34.1) n = 199

0.001

GLO, g/L

27.9 (25.1–31.5)

28 (24.7–31.0) n = 91

27.9 (25.2–31.6) n = 199

0.491

Creatinine, mg/dL

78 (62–129)

99 (61–200) n = 91

76 (62–110) n = 199

0.008

BUN, mmol/L

8.2 (5.6–13.5)

11.9 (6.8–18.2) n = 91

7 (5.2–11.7) n = 199

0.001

Sodium, mmol/L

139 (136–142)

139 (134–142) n = 90

139 (136–142) n = 199

0.167

Blood glucose, mmol/L

9.20 (6.9–13.1)

10.0(6.77–15.27) n = 84

8.8 (6.9–12.5) n = 181

0.031

ProBNP, ng/L

629 (201–2244)

696 (314–2683) n = 81

561 (175–2121) n = 181

0.363

CRP, mg/L

66.5 (26.0-127.1)

59.4 (21.1-135.2) n = 89

68.6 (28.1-119.1) n = 194

0.631

ESR, mm/hr

26 (15–42)

21 (15–41) n = 35

26 (15–43) n = 76

0.845

LDH, IU/L

354 (274–506)

449 (324–582) n = 80

345 (258–455) n = 186

0.037

Fet, ng/ml

1018(593–2351)

1369 (709–2688) n = 82

923(522–2151) n = 154

0.019

CD4 + lymphocytes, cell/µL

145.5(82.5-248.8)

108(45–180) n = 76

168(95–277) n = 144

0.037

CD8 + lymphocytes, cell/µL

119.5 (63–200)

72.5 (37–159) n = 76

129 (80–209) n = 144

0.414

IL-2,pg/mL

0.81 (0.1–1.51)

0.6 (0.1–1.25) n = 76

0.87 (0.1–1.55) n = 166

0.096

IL-4,pg/mL

0.1 (0.1–0.73)

0.1 (0.1–0.99) n = 76

0.1 (0.1–0.63) n = 166

0.795

IL-6,pg/mL

52.11(10.9-179.1)

32.7 (10.1-209.4) n = 76

58.7 (11.6–177) n = 166

0.485

IL-10,pg/mL

4.5 (0.79–13.90)

7.15(2.0-16.2) n = 76

4.2 (0.2–12.1) n = 166

0.314

TNF-a, pg/mL

0.1 (0.1–0.96)

0.10 (0.1–1.24) n = 76

0.1 (0.1–0.9) n = 166

0.124

IFN-r, pg/mL

1.87 (0.1–3.74)

1.87 (0.1–3.04) n = 76

1.85 (0.1–3.92) n = 166

0.088

IgG, g/L

10.71(8.5–12.9)

11.1 (9.1–13.2) n = 56

10.4 (8.55–12.9) n = 128

0.919

IgA, g/L

2.12 (1.5–3.05)

1.99 (1.43–2.98) n = 56

2.17 (1.63–3.08) n = 128

0.388

IgM, g/L

0.76 (0.52–1.07)

0.78 (0.55–1.15) n = 56

0.74 (0.51–1.04) n = 128

0.161

critical patients

105 (35.00%)

49 (53.84%)

56 (26.79%)

0.003

Treatments

Biologic agent

49 (16.33%)

9 (9.89%)

40 (19.13%)

0.068

Mechanical Ventilation

91 (30.33%)

45 (49.45%)

46 (22.00%)

0.001

CRRT

22 (7.33%)

17 (18.68%)

5 (2.39%)

0.001

vasopressor

38 (12.67%)

27 (29.67%)

11 (5.26%)

0.001

methylprednisolone ≥ 40 mg/d

89 (29.66%)

46 (50.05%)

43 (20.57%)

0.001

methylprednisolone (mg)

280 (120–480)

200 (120–397)

510 (160–510)

0.005

Length of hospitalization

12 (7–20)

16 (10–21)

19 (7–19)

0.019

Death or Automatic discharge

90 (30.00%)

43 (47.25%)

47 (22.48%)

0.001