Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content

Table 2 Risk factors associated with 28-day mortality in the matched patients with severe COVID-19

From: The clinical impact of prolonged steroid therapy in severe COVID-19 patients: a retrospective cohort study with propensity score matching

Variable

Univariate model

 

Multivariate model

 

Refined model

HR

95% CI

P value

 

Adjusted HR

95% CI

P value

 

Adjusted HR

95% CI

P value

Age

1.09

1.03–1.15

< 0.01

 

1.06

0.99–1.14

0.12

 

1.08

1.02–1.15

0.01

Variant of concern

1.80

0.70–4.66

0.22

 

-

-

-

 

-

-

-

Vaccination status

1.15

0.42–3.15

0.79

 

-

-

-

 

-

-

-

Obesity

0.22

0.05–1.03

0.05

 

0.40

0.07–2.20

0.29

 

-

-

-

Diabetes

0.83

0.22–3.14

0.79

 

-

-

-

 

-

-

-

Hypertension

1.07

0.33–3.51

0.91

 

-

-

-

 

-

-

-

Cardiovascular disease

1.64

0.43–6.18

0.47

 

-

-

-

 

-

-

-

Chronic lung disease

2.66

0.34–20.77

0.35

 

-

-

-

 

-

-

-

Chronic kidney disease

6.26

1.83–21.41

< 0.01

 

1.97

0.42–9.12

0.39

 

-

-

-

Solid malignancy

11.86

3.47–40.62

< 0.01

 

10.97

2.16–55.67

< 0.01

 

8.87

2.44–32.20

< 0.01

Hematologic malignancy

4.03

0.52–31.50

0.18

 

11.69

1.14-119.46

0.04

 

13.09

1.33-128.72

0.03

Mechanical ventilation (WHO-CPS 7–9)

1.57

0.48–5.15

0.45

 

-

-

-

 

-

-

-

SOFA score

1.18

0.95–1.48

0.14

 

1.11

0.82–1.50

0.51

 

-

-

-

Pronation

1.07

0.14–8.35

0.95

 

-

-

-

 

-

-

-

Lymphopenia

0.89

0.24–3.35

0.86

 

-

-

-

 

-

-

-

CRP level

1.01

0.94–1.09

0.74

 

-

-

-

 

-

-

-

Lactate dehydrogenase level

1.00

0.99–1.01

0.52

 

-

-

-

 

-

-

-

D-dimer level

1.05

1.01–1.09

0.02

 

0.98

0.92–1.04

0.49

 

-

-

-

Baricitinib

1.17

0.25–5.43

0.84

 

-

-

-

 

-

-

-

Tocilizumab

0.52

0.15–1.76

0.29

 

-

-

-

 

-

-

-

Prolonged steroid therapy

0.54

0.16–1.84

0.32

 

-

-

-

 

-

-

-

  1. Abbreviations: HR, hazard ratio; CI, confidence interval; WHO-CPS, World Health Organization-Clinical Progression Scale; SOFA, sequential organ failure assessment; CRP, C-reactive protein
Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us