Predictive value of neutrophil-lymphocyte ratio for all-cause mortality in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

Table 2 Subgroup analysis of mortality in COPD

Subgroup	Mortality(Classified variable)				Mortality(Continuity variable)
Subgroup	Study	OR [95%CI]	P value	I²	Study	OR [95%CI]	P value	I²
*Total*	15	1.03 [1.01, 1.06]	0.009	89%	24	1.23[0.90–1.57]	<0.00001	97%
*Follow-up*
≥ 90 days	6	2.14[1.20, 3.83]	<0.00001	93%	8	2.70[1.61,3.8]	<0.00001	99%
< 90 days	3	1.01[0.99,1.02]	0.05	68%	9	0.66[0.42,0.89]	<0.00001	81%
*Region*
Asia	10	1.04 [1.01,1.06]	0.005	91%	15	1.35 [0.86,1.85]	<0.00001	98%
Europe and Americas	3	1.00 [0.86, 1.16]	1	94%	4	0.46 [0.07, 0.86]	0.02	95%
Africa	1	1.13 [0.46, 2.78]	0.79	/	4	3.14 [1.13, 5.16]	0.002	95%
Oceania	1	0.95 [0.84, 1.07]	0.41	/	1	0.21 [-0.16, 0.57]	0.26	/
Population
COPD	4	1.44[0.89,2.31]	0.14	96%	9	1.06[0.58,1.54]	<0.00001	98%
AECOPD	11	1.02[1.00,1.03]	0.04	77%	15	1.30[0.81,1.78]	<0.00001	97%
Sample size
≥ 500	9	1.11[1.00, 1.23]	0.05	90%	13	1.26[0.84,1.69]	<0.00001	98%
<500	6	1.01[0.99,1.04]	0.27	88%	11	1.28[0.65,1.91]	<0.00001	96%
Mean age
≥ 70y	13	1.03[1.00, 1.06]	0.02	91%	17	1.18[0.78,1.58]	<0.00001	98%
<70y	2	1.03[0.96,1.11]	0.38	84%	6	1.47[0.59,2.35]	0.0002	93%
NLR cut-off
≥ 7	5	1.09[1.01,1.17]	0.03	87%	/	/	/	/
<7	5	1.91[1.,10, 3.34]	0.02	95%	/	/	/	/

ISSN: 1471-2466