Table 8 Reasons for dose modification, discontinuation and treatment pauses
Pirfenidone (Esbriet) (n = 17) | Nintedanib (Ofev) (n = 24) | |
|---|---|---|
Side Effects | ||
Nausea, vomiting, loss of appetite | 29% | 46% |
Photosensitivity and rash | 18% | 0% |
Diarrhea | 12% | 58% |
Clinical Efficacy | ||
Did not think the medication was working | 12% | 13% |
My lung function declined/tests showed progression of IPF | 0% | 4% |
Logistics & Access | ||
Logistics of managing/I forgot | 41% | 21% |
Refills were delayed | 6% | 4% |
Cost | 6% | 8% |
Another reason* | 24% | 13% |