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Table 2 Effects of ETI on quality of life determined by the CFQ-R

From: Unveiling the psychosocial impact of Elexacaftor/Tezacaftor/Ivacaftor therapy in Cystic Fibrosis patients

ITEM

Change between baseline and ETI 3 Months (CI95%)1

Change between baseline and ETI 6 Months (CI95%)

Change between baseline and ETI 12 Months (CI95%)

CFQ-R Respiratory

27.77 [ 16.67–27.77]

p< 0.001

27.77 [ 16.51–27.77]

p< 0.001

27.77 [ 11.11–27.77]

p< 0.001

CFQ-R Digestive

0.00 [−11.00– 0.001]

p = 0.299

11.10 [−11.11–11.11]

p = 0.247

11.10 [−1.33–11.11]

P= 0.003

CFQ-R Vitality

−8.33 [−16.66–8.33]

p = 0.830

0.00 [−8.33 − 8.33]

p = 0.691

11.10 [−4.35 − 11.11]

p= 0.003

CFQ-R Physical activity

16.66 [8.33–20.83]

p< 0.001

16.66 [7.61–20.83]

p< 0.001

25.00 [16.66 − 29.17]

p< 0.001

CFQ-R Food

11.11 [0.00–11.12]

p = 0.025

11.11 [−11.12–11.12]

p = 0.117

11.11 [ 0.00–11.12]

p= 0.007

CFQ-R Diary activity

8.34 [−8.34–8.34]

p< 0.001

8.34 [−8.33–8.34]

p= 0.004

8.34 [0.00–8.34]

p< 0.001

CFQ-R Treatment

0.00 [−11.11–0.00]

p = 0.594

0.00 [−11.11–0.00]

p = 0.841

0.00 [0.00–0.00]

p = 0.926

CFQ-R Emotional

0.00 [−13.33–6.67]

p= 0.016

3.33 [−6.67–6.66]

p= 0.002

13.33 [6.66–20.00]

p< 0.001

GAD-7

−2.00 [−4.00 – −2.00]

p = 0.0876

−1.00 [−3.00–0.00]

p = 0.381

−1.00 [−3.00–0.00]

p = 0.434

PHQ-9

−0.50 [−2.00–1.00]

p = 0.160

−1.50 [ −4.00 – −1.00]

p = 0.141

−0.50 [−2.00–1.00]

p = 0.193

  1. 1Confidence Interval 95% using a boostraping method (n = 9999)
  2. Significant comparisons (p < 0.05) are marked in bold