Table 3 Assessment of ETI effects on CFQ-R respiratory domain, PHQ-9 and GAD-7, stratifying by key factors
Questionaire | Change between baseline and ETI median (CI95%)1 | p-value | Change between baseline and ETI median (CI95%) | p-value | |
|---|---|---|---|---|---|
Groups | Female | Male | |||
CFQ-R respiratory domain | 27.77 [5.56–27.77] | < 0.001 | 22.22 [5.56–22.22] | < 0.001 | |
PHQ-9 | 0.0 [−2.80–0.00] | 0.330 | −0.5 [−2.00–0.00] | 0.067 | |
GAD-7 | 0.0 [−2.00 – −1.00] | 0.420 | −1.0 [−3.00–0.00] | 0.191 | |
Groups | Heterozygous F508del | Homozygous F508del | |||
CFQ-R respiratory domain | 27.77 [11.11–27.77] | < 0.001 | 22.2 [5.56–27.77] | < 0.001 | |
PHQ-9 | −1.0 [−3.00 – −1.00] | 0.536 | −1.0 [−3.00–0.00] | 0.020 | |
GAD-7 | −1.0 [−3.00 – −1.00] | 0.538 | −2.0 [−4.00– −2.00] | 0.098 | |
Groups | Median age < 28 years | Median age ≥ 28 years | |||
CFQ-R respiratory domain | 27.77 [ 11.11–27.77] | < 0.001 | 27.77 [16.66–27.77] | < 0.001 | |
PHQ-9 | −1.5 [−3.00–0.00] | 0.020 | −0.5 [−2.00–1.50] | 0.569 | |
GAD-7 | −1.0 [−3.00 – −0.50] | 0.098 | −1 [−3.50–0.00] | 0.605 | |
Groups | Median FEV1% <63.5 | Median FEV1% ≥63.5 | |||
CFQ-R respiratory domain | 27.77 [16.66–33.33] | < 0.001 | 27.77 [11.11–27.77] | < 0.001 | |
PHQ-9 | −0.5 [−2.00–1.00] | 0.211 | −1.5 [−3.50 – −0.50] | 0.120 | |
GAD-7 | −1.0 [−3.00– −1.00] | 0.183 | −0.5 [−2.00–1.50] | 0.362 | |
Groups | Pseudomonas aeruginosa absence | Pseudomonas aeruginosa presence | |||
CFQ-R respiratory domain | 27.77 [11.11–27.77] | < 0.001 | 27.77 [ 11.11–27.77] | < 0.001 | |
PHQ-9 | −1.0 [−3.00–0.00] | 0.053 | −1.00 [−3.00–0.00] | 0.403 | |
GAD-7 | −1.0 [−2.50 – −0.50] | 0.079 | 0.0 [−2.00–1.00] | 0.800 | |