Table 1 Clinical characteristics of LUAD patients and LUSC patients
Clinical characteristics | Overall | LUAD (N = 2476) | P | LUSC (N = 523) | P | ||
|---|---|---|---|---|---|---|---|
(N = 3185) | I-III (N = 811) | IV (N = 1665) | I-III (N = 120) | IV (N = 403) | |||
n (%) | n (%) | n (%) | n (%) | n (%) | |||
Age (median, range) | 61 (11–90) | 58 (11–85) | 61 (25–90) | < 0.001 | 64 (33–85) | 65 (30–87) | 0.359 |
Sex | Â | Â | |||||
Male | 1892 (59.40) | 393 (48.46) | 902 (54.17) | 0.0075 | 110 (91.67) | 358 (88.83) | 0.375 |
Female | 1293 (40.60) | 418 (51.54) | 763 (45.83) | 10 (8.33) | 45 (11.17) | ||
Smoking status |  | < 0.001 |  |  | 0.046 | ||
Ever | 1068 (33.53) | 154 (18.99) | 408 (24.50) | Â | 105 (87.50) | 324 (80.40) | Â |
Never | 1427 (44.71) | 463 (57.09) | 857 (51.47) | 7 (5.83) | 49 (12.16) | ||
Unknown | 690 (21.66) | 194 (23.92) | 400 (24.02) | 8 (6.67) | 30 (7.44) | ||
PD-L1 expression |  | < 0.001 |  |  | 0.058 | ||
High | 457 (14.35) | 61 (7.52) | 266 (15.98) | Â | 22 (18.33) | 84 (20.84) | Â |
Low | 1131 (35.51) | 270 (33.29) | 582 (34.95) | 63 (52.50) | 163 (40.45) | Â | |
Negative | 1597 (50.14) | 480 (59.19) | 817 (49.07) | 35 (29.17) | 156 (38.17) | Â | |
TMB |  |  | < 0.001 |  | 0.597 | ||
TMB-H | 747 (23.45) | 95 (11.71) | 284 (17.06) | Â | 68 (56.67) | 241 (59.80) | Â |
TMB-L | 2438 (76.55) | 716 (88.29) | 1381 (82.94) | Â | 52 (43.33) | 162 (40.20) | Â |
TMB (median, range) | 4 (0-995) | 2 (0-121.91) | 3.84 (0-995) | 0.012 | 10.56 (0-935.04) | 10.56 (0-312) | 0.123 |