Table 2 Clinical characteristics of different PD-L1 expression cohorts in LUAD and LUSC
PD-L1 expression level | LUAD (n = 2476) | |||||||
|---|---|---|---|---|---|---|---|---|
I-III (n = 811) |  | IV (n = 1665) |  | |||||
High(n = 61) | Low(n = 270) | Negative (n = 480) | P | High(n = 266) | Low(n = 582) | Negative (n = 817) | P | |
n (%) | n (%) | n (%) |  | n (%) | n (%) | n (%) |  | |
Age (median, range) | 64 (26–82) | 61 (11–84) | 61 (25–85) | 0.037 | 61 (29–90) | 61 (28–90) | 61 (28–90) | 0.493 |
Sex |  | < 0.001 |  | < 0.001 | ||||
Male | 43 (70.49) | 149 (55.19) | 201 (41.88) | Â | 179 (67.29) | 311 (53.44) | 412 (50.43) | Â |
Female | 18 (29.51) | 121 (44.81) | 279 (58.13) | 87 (32.71) | 271 (46.56) | 405 (49.57) | ||
Smoking status |  | < 0.001 |  | < 0.001 | ||||
Ever | 17 (27.87) | 61 (22.59) | 76 (15.83) | Â | 85 (31.95) | 140 (24.05) | 183 (22.40) | Â |
Never | 20 (32.79) | 140 (51.85) | 299 (62.29) | 108 (40.60) | 308 (52.92) | 441 (53.98) | ||
Unknown | 24 (39.34) | 69 (25.56) | 105 (21.88) | 73 (27.44) | 13 (23.02) | 193 (23.62) | ||
PD-L1 expression level | LUSC (n = 523) | |||||||
|---|---|---|---|---|---|---|---|---|
I-III (n = 120) |  | IV (n = 403) |  | |||||
High(n = 22) | Low(n = 63) | Negative (n = 35) | P | High(n = 84) | Low(n = 163) | Negative (n = 156) | P | |
n (%) | n (%) | n (%) | Â | n (%) | n (%) | n (%) | Â | |
Age (median, range) | 62 (33–75) | 62 (35–85) | 61 (44–81) | 0.1276 | 61 (32–87) | 61 (30–85) | 62 (40–84) | 0.5766 |
Sex | Â | 0.6770 | Â | 0.5475 | ||||
Male | 20 (90.91) | 59 (93.65) | 31 (88.57) | Â | 72 (85.71) | 145 (88.96) | 141 (90.38) | Â |
Female | 2 (9.09) | 4 (6.35) | 4 (11.43) | 12 (14.29) | 18 (11.04) | 15 (9.62) | ||
Smoking status | Â | 0.6422 | Â | 0.7484 | ||||
Ever | 19 (86.36) | 56 (88.89) | 30 (85.71) | Â | 67 (79.76) | 132 (80.98) | 125 (80.13) | Â |
Never | 2 (9.09) | 4 (6.35) | 1 (2.86) | 8 (9.52) | 22 (13.50) | 19 (12.18) | ||
Unknown | 1 (4.55) | 3 (4.76) | 4 (11.43) | 9 (10.71) | 9 (5.52) | 12 (7.69) | ||